1245152-13-9

Basic information

• Product Name: 3-O-(3'-methylphthalyl)-betulinic acid
• Synonyms: 3-O-(3'-methylphthalyl)-betulinic acid
• CAS NO: 1245152-13-9
• Molecular Weight: 618.854
• Mol File: 1245152-13-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-O-(3'-methylphthalyl)-betulinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-O-(3'-methylphthalyl)-betulinic acid(1245152-13-9)
• EPA Substance Registry System: 3-O-(3'-methylphthalyl)-betulinic acid(1245152-13-9)

Safety Data

• Hazardous Substances Data: 1245152-13-9(Hazardous Substances Data)

Upstream product

• 4792-30-7 3-methylphthalic acid anhydride 
• 472-15-1 Betulinic acid 

Relevant articles and documents

Anticancer activity of 3-O-acylated betulinic acid derivatives obtained by enzymatic synthesis

An easy and efficient strategy to prepare betulinic acid esters with various anhydrides was used by the enzymatic synthesis method. It involves lipase-catalyzed acylation of betulinic acid with anhydrides as acylating agents in organic solvent. Lipase from Candida antarctica immobilized on an acrylic resin (Novozym 435) was employed as a biocatalyst. Several 3-O-acyl-betulinic acid derivatives were successfully obtained by this procedure. The anticancer activity of betulinic acid and its 3-O-acylated derivatives were then evaluated in vitro against human lung carcinoma (A549) and human ovarian (CAOV3) cancer cell lines. 3-O-glutarylbetulinic acid, 3-O-acetyl-betulinic acid, and 3-O-succinyl-betulinic acid showed IC50 10 μg/ml against A549 cancer cell line tested and showed better cytotoxicity than betulinic acid. In an ovarian cancer cell line, all betulinic acid derivatives prepared showed weaker cytotoxicity than betulinic acid.