1245506-62-0

Basic information

• Product Name: 2-Chloro-5-hydroxy-4-MethylpyriMidine
• Synonyms: 2-Chloro-5-hydroxy-4-MethylpyriMidine;2-Chloro-4-methylpyrimidin-5-ol;2-chloro-4-methyl-5-Pyrimidinol
• CAS NO: 1245506-62-0
• Molecular Formula: C₅H₅ClN₂O
• Molecular Weight: 144.559
• Mol File: 1245506-62-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-Chloro-5-hydroxy-4-MethylpyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-hydroxy-4-MethylpyriMidine(1245506-62-0)
• EPA Substance Registry System: 2-Chloro-5-hydroxy-4-MethylpyriMidine(1245506-62-0)

Safety Data

• Hazardous Substances Data: 1245506-62-0(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-hydroxy-4-MethylpyriMidine is a chemical compound with the molecular formula C5H6ClN2O. It is a chlorinated derivative of the nucleoside cytidine and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-Chloro-5-hydroxy-4-MethylpyriMidine is a white to off-white crystalline powder that is sparingly soluble in water but more soluble in organic solvents. It is important to handle this compound with care as it may be harmful if ingested or inhaled, and can cause irritation to the eyes, skin, and respiratory system. It is also important to follow proper safety precautions when working with this chemical, including the use of appropriate personal protective equipment and working in a well-ventilated area.

Upstream product

• 1245506-61-9 2-chloro-5-methoxy-4-methylpyrimidine 

Downstream Products

• 1369768-95-5 (1R,2S)-2-{[(2-chloro-4-methylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarboxylic acid 
• 1369768-94-4 (1R,2S)-2-{[(2-chloro-4-methylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropanecarbaldehyde 
• 1369768-93-3 {(1R,2S)-2-{[(2-chloro-4-methylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)cyclopropyl}methanol 
• 1369766-63-1 5-Benzyloxy-2-ethyl-4-methylpyrimidine 
• 1369766-60-8 5-Benzyloxy-2-chloro-4-methylpyrimidine 
• 1351345-55-5 [(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 1351338-59-4 (3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine p-toluenesulfonate 
• 1351345-54-4 ((3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}pyrrolidin-3-yl)carbamic acid tert-butyl ester 

Relevant articles and documents

CYCLOHEXYL ACID PYRAZOLE AZINES AS LPA ANTAGONISTS

The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

CYCLOPROPANE COMPOUND

A cyclopropane compound represented by the following formula (A) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism, and therefore has a potencial of usefulness for the treatment of sleep disorder for which orexin receptor antagonism is effective, for example, insomnia: wherein Q represents —CH— or a nitrogen atom, R1a and R1b each independently represent a C1-6 alkyl group and the like, R1c represents a hydrogen atom and the like, R2a, R2b, R2c and R2d each independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group and the like, R3a, R3b and R3c each independently represent a hydrogen atom, a halogen atom and the like, and R3d represents a hydrogen atom and the like.

COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS

The present invention is directed to therapeutic compotmds of the following formula (I) which have activity as agonists of GPR 119 and are useful for the treatment of metabolic disorders including type II diabetes.