1245648-36-5 Usage
General Description
7-Bromo-4-fluoroindoline-2,3-dione is a chemical compound with the molecular formula C8H4BrFNO2. It is an organic compound containing both bromine and fluorine atoms. 7-Bromo-4-fluoroindoline-2,3-dione is commonly used in pharmaceutical and chemical research as a building block in the synthesis of various bioactive molecules. It is known for its versatile reactivity and has been utilized in the development of potential drug candidates and agrochemicals. Furthermore, 7-Bromo-4-fluoroindoline-2,3-dione has also been studied for its potential anti-inflammatory and antitumor properties. Its unique chemical structure and properties make it a valuable compound in the field of medicinal and pharmaceutical chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 1245648-36-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,5,6,4 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1245648-36:
(9*1)+(8*2)+(7*4)+(6*5)+(5*6)+(4*4)+(3*8)+(2*3)+(1*6)=165
165 % 10 = 5
So 1245648-36-5 is a valid CAS Registry Number.
InChI:InChI=1S/C8H3BrFNO2/c9-3-1-2-4(10)5-6(3)11-8(13)7(5)12/h1-2H,(H,11,12,13)
1245648-36-5Relevant articles and documents
Preparation method of 4-fluoro-7-bromoisatin
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Paragraph 0023; 0026-0028; 0031-0033; 0036-0037, (2020/05/02)
The invention discloses a preparation method of 4-fluoro-7-bromoisatin, and belongs to the field of synthesis of medical intermediates. The preparation method comprises the following steps: condensing2-bromo-5-fluoroaniline, taken as a raw material, with chloral hydrate and hydroxylamine hydrochloride in an ethanol-sodium sulfate-water system; and then performing cyclization in concentrated sulfuric acid, and performing recrystallization with ethyl alcohol-water to obtain the 4-fluoro-7-bromoisatin. Experiment conditions are improved to develop the ethanol-water-sodium sulfate mixed solvent system; and compared with a literature method, th method of the invention has the following advantages: the yield is improved to a certain extent, the consumption of sodium sulfate is reduced, an intermediate isonitrosoacetanilide can meet the purity requirement of next-step cyclization without purification, the product purity reaches up to 99% or above, and industrial amplification is facilitated.
