1245649-52-8

Basic information

• Product Name: 4-CHLORO-5-NITRO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE
• Synonyms: 4-CHLORO-5-NITRO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE;1-(benzenesulfonyl)-4-chloro-5-nitropyrrolo[2,3-b]pyridine;1-(benzenesulfonyl)-4-chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine;4-Chloro-5-nitro-1-(phenylsulfonyl);4-Chloro-5-nitro-1-(phenylsulfonyl)-7-azaindole;1H-Pyrrolo[2,3-b]pyridine, 4-chloro-5-nitro-1-(phenylsulfonyl)-
• CAS NO: 1245649-52-8
• Molecular Formula: C₁₃H₈ClN₃O₄S
• Molecular Weight: 337.73832
• EINECS: -0
• Mol File: 1245649-52-8.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 539.9±60.0 °C(Predicted)
• Appearance: /
• Density: 1.63±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.67±0.30(Predicted)
• CAS DataBase Reference: 4-CHLORO-5-NITRO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5-NITRO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE(1245649-52-8)
• EPA Substance Registry System: 4-CHLORO-5-NITRO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE(1245649-52-8)

Safety Data

• Hazardous Substances Data: 1245649-52-8(Hazardous Substances Data)

Usage

General Description

4-Chloro-5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine is a specific chemical compound that is known for its extensive use in chemical research. 4-CHLORO-5-NITRO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE is characterized by its unique structural formation, which includes chlorine, nitro, and phenylsulfonyl functional groups attached to a pyrrolopyridine core. Despite the limited information on its specific properties or effects, this compound is utilized primarily as a reagent or intermediate in various chemical syntheses due to its ability to undergo a range of reactions. Typical handling precautions apply due to the compound's potential reactive or hazardous nature.

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 744209-63-0 1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine 
• 55052-28-3 4-chloro-7-azaindole 
• 271-63-6 7-Azaindole 

Downstream Products

• 1315494-64-4 C₂₁H₂₃N₅O₆S 
• 1315484-23-1 [4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(6H)-yl)-piperidin-1-yl]phenylmethanone 
• 1315484-43-5 1-(1-phenylsulfonyl-piperidin-4-yl)-1,6-dihydro-imidazo[4,5-d]pyrrolo[2,3-b]pyridine 

Relevant articles and documents

NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF

The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.

Design and synthesis of 7-azaindole derivatives and their antitumor and analgesic activities

To develop effective anti-tumor and analgesic drugs, a series of novel 7-azaindole derivatives were designed and synthesized through a four-step reaction. 18 target compounds were obtained and characterized through Nuclear Magnetic Resonance and High Resolution Mass Spectrometry. Their anti-proliferative activities and analgesic effect were evaluated. When the 1-position was a methylsulfonyl group and the 5-position was a nitro group, compound 4f demonstrated the best activity. Furthermore, there was a dramatic difference between the IC50 values of compound 4f in tumor and in healthy cell line. The IC50 values of compound 4f in MCF7 breast cancer cell line was 5.781 μmol/L and 8.077 μmol/L in HepG2 hepatoma carcinoma cell line, but more than 100 μmol/L in HL7702 liver cell line. Preliminary results showed that compounds 3a, 3g and 4i had significant analgesic effects in mice, which were stronger than aspirin. These compounds have good prospects for new drug development.

A new synthetic process of the pyrrole compounds and the use of the anti-tumor effect (by machine translation)

The present invention discloses a new synthetic process of the pyrrole compounds and the use of the anti-tumor effect, and in particular relates to compounds 1 - benzenesulfonyl - 4 - chloro - 5 - nitro - 1 H - pyrrolo [2, 3 - b] pyridine, hydrate and its salt of new synthetic process and the use of the anti-tumor effect, this synthesis process takes 1 H - pyrrolo [2, 3 - b] pyridine as the starting material, after chloro-, prepared by acylation reaction such as 1 - benzenesulfonyl - 4 - chloro - 5 - nitro - 1 H - pyrrolo [2, 3 - b] pyridine, hydrate and its salt, provides a simple operation, high yield of the new process, the preparation method is simple, mild reaction conditions, at the same time the compound anti-tumor activity is prominent, little toxicity to normal cell, is favorable to its anti-tumor field widely popularized. (by machine translation)