1246638-08-3

Basic information

• Product Name: N-DeMethyl Ivabradine Hydrochloride
• Synonyms: N-DeMethyl Ivabradine Hydrochloride;3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]aMino]propyl]-1,3,4,5-tetrahydro-7,8-diMethoxy-3-benzazepin-2-one Hydrochloride;S 18982;N-DesMethyl Ivabradine Hydrochloride;Ivabradine metabolite N-Demethyl Ivabradine (hydrochloride);N-Desmethyl Ivabradine HCl;Ivabradine Impurity b;N-Demethyl Ivabradine-d6 HCl
• CAS NO: 1246638-08-3
• Molecular Formula: C26H35ClN2O5
• Molecular Weight: 491.0195
• Product Categories: Amines;Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 1246638-08-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 193-196°C
• Appearance: /
• Storage Temp.: Refrigerator
• CAS DataBase Reference: N-DeMethyl Ivabradine Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-DeMethyl Ivabradine Hydrochloride(1246638-08-3)
• EPA Substance Registry System: N-DeMethyl Ivabradine Hydrochloride(1246638-08-3)

Safety Data

• Hazardous Substances Data: 1246638-08-3(Hazardous Substances Data)

Usage

Description

N-DeMethyl Ivabradine Hydrochloride, also known as N-desmethyl Ivabradine, is an active metabolite of the pharmaceutical drug Ivabradine. It is produced through the metabolism of Ivabradine by the cytochrome P450 (CYP) isoform CYP3A4. This beige solid is a key component in understanding the drug's efficacy and pharmacokinetics.

Uses

Used in Pharmaceutical Industry:
N-DeMethyl Ivabradine Hydrochloride is used as a research compound for studying the metabolism and pharmacological effects of Ivabradine. It aids in understanding the drug's mechanism of action, bioavailability, and potential side effects, which is crucial for optimizing therapeutic applications and dosages.
Used in Drug Development:
As an active metabolite, N-DeMethyl Ivabradine Hydrochloride is utilized in drug development processes to evaluate the safety and efficacy of Ivabradine. It helps in assessing the drug's potential for treating specific conditions and contributes to the overall development of new medications.
Used in Quality Control:
N-DeMethyl Ivabradine Hydrochloride is used as a reference standard in quality control testing for Ivabradine-containing pharmaceutical products. It ensures that the drug meets the required purity and potency standards, maintaining the safety and efficacy of the medication for patients.

Upstream product

• 215935-23-2 N-Demethyl Ivabradine 

Relevant articles and documents

Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.