124832-31-1Relevant articles and documents
PROCESS FOR THE PREPARATION OF VALACYCLOVIR HYDROCHLORIDE
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Paragraph 0040, (2014/10/16)
The present invention provides a process for the preparation of 2-[(2-amino-1,6-dihydro-6-oxo-9H-yl)]ethyl L-valine ester hydrochloride (valacyclovir hydrochloride) of formula I comprising deprotection of N-[(benzyloxy)carbonyl]-L-valine-2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester, of formula II using 5% palladium on carbon as a catalyst and mineral acid in the presence of water, avoiding use of organic solvents under hydrogen pressure to yield valacyclovir hydrochloride having yield of ≧90% and purity of ≧99.5%, pharmaceutically acceptable grade. The valacyclovir hydrochloride obtained using the process of the present invention is valacyclovir hydrochloride polymorphic Form I.
VALACYCLOVIR PROCESS
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Page/Page column 1; 5-6, (2010/11/27)
A process for preparing valacyclovir or a salt thereof.
USE OF VALACICLOVIR FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF GENITAL HERPES BY A SINGLE DAILY APPLICATION
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, (2008/06/13)
The invention relates to the antiviral drug valaciclovir, the valine ester of 9-[(2-hydroxyethoxy)methyl]guanine (aciclovir), which is known as an effective treatment for genital herpes in a dosage regime of 40 mg, twice to 5 times daily. More specificall