124995-02-4

Basic information

• Product Name: Carbamic acid, [1-(hydroxymethyl)-2-phenylethyl]-, 1-methylethyl ester, (S)-
• CAS NO: 124995-02-4
• Molecular Formula: C13H19NO3
• Molecular Weight: 237.299
• Mol File: 124995-02-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [1-(hydroxymethyl)-2-phenylethyl]-, 1-methylethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [1-(hydroxymethyl)-2-phenylethyl]-, 1-methylethyl ester, (S)-(124995-02-4)
• EPA Substance Registry System: Carbamic acid, [1-(hydroxymethyl)-2-phenylethyl]-, 1-methylethyl ester, (S)-(124995-02-4)

Safety Data

• Hazardous Substances Data: 124995-02-4(Hazardous Substances Data)

Upstream product

• 124947-31-5 N-(isopropoxycarbonyl)-L-phenylalanine methyl ester 
• 63-91-2 L-phenylalanine 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 

Downstream Products

• 128540-54-5 (S)-3-cyclohexyl-2-(isopropoxycarbonyl)aminopropanol 
• 128540-55-6 2-acetoxy-4-cyclohexyl-3-(isopropoxycarbonylamino) butyronitrile 
• 138448-73-4 methyl <(4S,5S)-4-cyclohexylmethyl-2,2-dimethyl-3-isopropoxycarbonyl-1,3-oxazolidin-5-yl>acetate 
• 138448-74-5 methyl <(4S,5R)-4-cyclohexylmethyl-2,2-dimethyl-3-isopropoxycarbonyl-1,3-oxazolidin-5-yl>acetate 
• 128625-48-9 methyl (3S,4S)-5-cyclohexyl-3-hydroxy-4-(isopropoxycarbonyl)aminopentanoate 
• 128625-50-3 methyl (3R,4S)-5-cyclohexyl-3-hydroxy-4-(isopropoxycarbonyl)aminopentanoate 
• 105192-90-3 ACHPA 
• 128540-53-4 (S)-3-cyclohexyl-2-(isopropoxycarbonyl)aminopropanol 

Relevant articles and documents

An expeditious synthesis of (3S,4S)-statine and (3S,4S)cyclohexylstatine

The title synthesis could be accomplished by employing highly stereoselective aldol reaction of O-methyl-O-trimethylsilyl ketene acetal with the (S)-α-amido aldehyde (2) in the presence of titanium (IV) chloride as a key step.

A highly stereoselective synthesis of (3S,4S)-statine and (3S,4S)-cyclohexylstatine

The title compounds, which are synthetic intermediates of renin inhibitors, could be prepared from (S)-leucine and (S)-phenylalanine, respectively, by employing highly stereoselective aldol reactions of O-methyl-O-trimethylsilyl ketene acetal with an (S)-