1250998-93-6 Usage
General Description
N-BOC-3-(iodomethyl)-2-oxa-8-azaspiro[4.5]decane is a chemical compound with a spirocyclic structure that features an azaspiro group and an iodomethyl substituent. It is used in organic synthesis and medicinal chemistry as a versatile building block for the preparation of various heterocyclic compounds. The BOC (tert-butoxycarbonyl) protecting group can be selectively removed under mild conditions, allowing for further functionalization of the molecule. The iodomethyl group can undergo nucleophilic substitution reactions, making the compound useful for introducing iodine atoms into organic molecules. Overall, N-BOC-3-(iodomethyl)-2-oxa-8-azaspiro[4.5]decane is a valuable intermediate in the synthesis of diverse biologically active substances and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 1250998-93-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,0,9,9 and 8 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1250998-93:
(9*1)+(8*2)+(7*5)+(6*0)+(5*9)+(4*9)+(3*8)+(2*9)+(1*3)=186
186 % 10 = 6
So 1250998-93-6 is a valid CAS Registry Number.
InChI:InChI=1S/C14H24INO3/c1-13(2,3)19-12(17)16-6-4-14(5-7-16)8-11(9-15)18-10-14/h11H,4-10H2,1-3H3
1250998-93-6Relevant articles and documents
Oxa-spirocycles: synthesis, properties and applications
Badlo, Valentyn R.,Bolbut, Andrii V.,Borysko, Petro,Diachuk, Taras,Dmytriv, Yurii V.,Fominova, Kateryna,Granat, Dmitry,Iminov, Rustam,Kovalchuk, Igor,Kuznetsova, Anastasiia S.,Kuznietsova, Halyna,Levterov, Vadym V.,Litskan, Eduard,Meliantsev, Vladyslav,Mykhailiuk, Pavel K.,Pavlova, Olexandra,Pishel, Iryna,Ripenko, Vasyl,Savchuk, Taras,Semeno, Volodymyr V.,Shvydenko, Kostiantyn,Svitlychnyi, Oleksiy,Tolmachev, Andrei A.,Vaskevych, Alla I.,Vaskevych, Ruslan I.,Vilchynskyi, Vladyslav,Vysochyn, Daniil
, p. 11294 - 11305 (2021/09/08)
A general approach to a new generation of spirocyclic molecules - oxa-spirocycles - was developed. The key synthetic step was iodocyclization. More than 150 oxa-spirocyclic compounds were prepared. Incorporation of an oxygen atom into the spirocyclic unit dramatically improved water solubility (by up to 40 times) and lowered lipophilicity. More potent oxa-spirocyclic analogues of antihypertensive drug terazosin were synthesized and studiedin vivo.
