1251537-48-0

Basic information

• Product Name: 1-BENZYL-PIPERIDINE-4-BORONIC ACID
• Synonyms: 1-BENZYL-PIPERIDINE-4-BORONIC ACID;(1-Benzylpiperidin-4-yl)boronic acid
• CAS NO: 1251537-48-0
• Molecular Formula: C₁₂H₁₈BNO₂
• Molecular Weight: 219.09
• Mol File: 1251537-48-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BENZYL-PIPERIDINE-4-BORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-PIPERIDINE-4-BORONIC ACID(1251537-48-0)
• EPA Substance Registry System: 1-BENZYL-PIPERIDINE-4-BORONIC ACID(1251537-48-0)

Safety Data

• Hazardous Substances Data: 1251537-48-0(Hazardous Substances Data)

Usage

General Description

1-Benzyl-piperidine-4-boronic acid is a chemical compound that is commonly used in organic synthesis and medicinal chemistry. It is an organoboronic acid derivative that contains a piperidine ring with a benzyl group attached to it. The boronic acid functionality makes it a useful reagent for Suzuki-Miyaura cross-coupling reactions, which are important in the synthesis of complex organic molecules. Additionally, the piperidine ring is commonly found in many pharmaceuticals and bioactive compounds, making this compound a valuable intermediate in drug discovery and development. Overall, 1-benzyl-piperidine-4-boronic acid plays a significant role in the field of organic chemistry and pharmaceutical research.

Upstream product

• 4727-72-4 1-benzyl-4-hydroxypiperidine 
• 67848-71-9 4-chloro-1-benzylpiperidine 
• 6562-41-0 chloro-bis(dimethylamino)borane 
• 7732-18-5 water 

Relevant articles and documents

Process method for synthesizing N-substituted piperidine-4-boric acid

The invention relates to an organic compound synthesis method, and relates to a process method for synthesizing N-substituted piperidine-4-boric acid, which comprises the following steps of: reactingN-substituted piperidine-4-alcohol used as a raw material with thionyl chloride and organic alkali in a solvent to generate N-substituted piperidine-4-chlorine, reacting the N-substituted piperidine-4-chlorine used as a raw material with lithium metal and bis (N, N-dimethylamino) borane halide in a solvent, quenching and acidifying to obtain N-substituted piperidine-4-boric acid. The process method has the advantages of originality, low cost, safety and mild reaction conditions, avoids the dangerous reaction that other patented methods adopt expensive palladium hydroxide hydrogenation, has potential cost advantage and safety advantage, and is suitable for industrial scale-up production.

INHIBITORS OF FATTY ACID AMIDE HYDROLASE

Provided herein are compounds of formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof or mixtures thereof, wherein Z1, Z2, X1, X2, X3, R1, R2 R3/