1251854-62-2Relevant articles and documents
Synthesis of the revised structure of acortatarin A
Geng, Hui Min,Stubbing, Louise A.,Li-Yang Chen, Jack,Furkert, Daniel P.,Brimble, Margaret A.
, p. 6227 - 6241 (2015/03/30)
A novel Maillard-type condensation between a primary amine derived from D-mannitol and a dihydropyranone, was used as a key step to access the unusual morpholine-spiroketal acortatarin A. The synthetic approach also enabled access to a C-2 analogue of acortatarin A, and can be used for the synthesis of related 2-formylpyrrole natural products.
An efficient and enantioselective total synthesis of naturally occurring L-783277
Choi, Hwan Geun,Son, Jung Beom,Park, Dong-Sik,Ham, Young Jin,Hah, Jung-Mi,Sim, Taebo
scheme or table, p. 4942 - 4946 (2011/01/04)
Naturally occurring L-783277 which belongs to 14-membered resorcylic acid lactones (RALs) turned out to be a potent kinase inhibitor against MEK (MAP kinase kinase). We successfully accomplished efficient and enantioselective total synthesis of L-783277 based on convergent assembly of one aromatic unit and two chiral building blocks with efficient orthogonal protection-deprotection strategy. Three key steps composed of olefin cross metathesis, addition of acetylene derivative to aldehyde, and Yamaguchi macrolactonization were subsequently employed to construct the framework of L-783277. The optical rotation value of L-783277 is for the first time presented in this Letter.
