1251936-44-3

Basic information

• Product Name: 1-[4-(2-Amino-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol
• Synonyms: 1-[4-(2-Amino-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol
• CAS NO: 1251936-44-3
• Molecular Weight: 388.466
• Mol File: 1251936-44-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[4-(2-Amino-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(2-Amino-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol(1251936-44-3)
• EPA Substance Registry System: 1-[4-(2-Amino-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol(1251936-44-3)

Safety Data

• Hazardous Substances Data: 1251936-44-3(Hazardous Substances Data)

Upstream product

• 623-05-2 (4-hydroxyphenyl)methanol 
• 123226-38-0 4-hydroxymethyl-phenoxy acetonitrile 
• 112772-83-5 4-chloromethyl phenoxy acetonitrile 

Downstream Products

• 198481-32-2 bazedoxifene 
• 198481-33-3 bazedoxifene acetate 
• 1251936-45-4 1-(2-{4-[5-Hydroxy-2-(4-hydroxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-ethyl)-azepane-2,7-dione 

Relevant articles and documents

PROCESSES FOR THE SYNTHESIS OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF

Efficient processes for the synthesis of pharmaceutically useful compounds such as (1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxy-phenyl)-3-methyl-1H-indol-5-ol acetic acid commonly known as bazedoxifene acetate (Formula IX) using cyanomethoxybenzyl halides of Formula III, where X=Halogens e.g., Cl, F, Br, I; G=Any electron donating or electron withdrawing substituent.