1253-46-9

Basic information

• Product Name: 4-CARBOMETHOXYBENZYL TRIPHENYLPHOSPHONIUM CHLORIDE
• Synonyms: Methyl-alpha-(triphenylphosphonio)-p-toluatebromide;methyl à(triphenylphosphonio)-p-toluate bromide;(4-METHOXYCARBONYLBENZYL)TRIPHENYLPHOSPHONIUM BROMIDE;4-METHOXYCARBONYL-BENZYLTRIPHENYLPHOSPHONIUM CHLORIDE;4-CARBOMETHOXYBENZYL TRIPHENYLPHOSPHONIUM CHLORIDE;(4-Carbomethoxybenzyl)triphenylphosphonium bromide~Methyl alpha(triphenylphosphonio)-p-toluate bromide;(4-Methoxycarbonylbenzyl)Triphenylphosphonium Bromide(WXC02949)
• CAS NO: 1253-46-9
• Molecular Formula: Br*C₂₇H₂₄O₂P
• Molecular Weight: 491.36
• Mol File: 1253-46-9.mol
• Article Data: 25

Chemical Properties

• Melting Point: 258-260°C
• Appearance: White crystalline powder
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Soluble in ethanol. Slightly soluble in water.
• Sensitive: Hygroscopic
• BRN: 6535869
• CAS DataBase Reference: 4-CARBOMETHOXYBENZYL TRIPHENYLPHOSPHONIUM CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CARBOMETHOXYBENZYL TRIPHENYLPHOSPHONIUM CHLORIDE(1253-46-9)
• EPA Substance Registry System: 4-CARBOMETHOXYBENZYL TRIPHENYLPHOSPHONIUM CHLORIDE(1253-46-9)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 1253-46-9(Hazardous Substances Data)

Usage

Uses

Useful intermediate for pharmaceutical and organic synthesis.

InChI:InChI=1/C27H24O2P.ClH/c1-29-27(28)23-19-17-22(18-20-23)21-30(24-11-5-2-6-12-24,25-13-7-3-8-14-25)26-15-9-4-10-16-26;/h2-20H,21H2,1H3;1H/q+1;/p-1

Upstream product

• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 603-35-0 triphenylphosphine 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 6232-88-8 4-bromomethylbenzoic Acid 

Downstream Products

• 128587-60-0 4-((E)-2-Furan-2-yl-vinyl)-benzoic acid methyl ester 
• 63368-28-5 4-Methoxycarbonyl-3'-benzyloxy-4'-methoxystilben 
• 79370-16-4 trans-4-Methoxy-4'-stilbencarbonsaeure-methylester 
• 292059-34-8 N-benzoyl-4-[4-(carboxymethyl)benzylidene]piperidine 
• 292059-44-0 N-(trimethyl)acetyl-4-[4-(carboxymethyl)benzylidene]piperidine 
• 292059-45-1 N-(3,3-dimethyl)acryloyl-4-[4-(carboxymethyl)benzylidene]piperidine 
• 292059-42-8 N-(2-propyl)pentanoyl-4-[4-(carboxymethyl)benzylidene]piperidine 
• 292059-37-1 N-cyclohexanoyl-4-[4-(carboxymethyl)benzylidene]piperidine 
• 292059-39-3 N-(cyclohexyl)acetyl-4-[4-(carboxymethyl)benzylidene]piperidine 
• 292059-43-9 N-(diphenyl)carbamoyl-4-[4-(carboxymethyl)benzylidene]piperidine 
• 1149-18-4 (E)-methyl 4-styrylbenzoate 
• 455323-46-3 N-(3,3-diphenyl)propanoyl-4-[4-(methoxycarbonyl)benzylidene]piperidine 
• 360789-58-8 4-<2-(3,4,5-trimethoxyphenyl)ethenyl>benzoic acid methyl ester 
• 209688-08-4 methyl 4-[2-(5-chloro-2-nitrophenyl)vinyl]benzoate 

Relevant articles and documents

Balancing Mechanical Stability and Ultrahigh Porosity in Crystalline Framework Materials

A new mesoporous metal–organic framework (MOF; DUT-60) was conceptually designed in silico using Zn4O6+ nodes, ditopic and tritopic linkers to explore the stability limits of framework architectures with ultrahigh porosity. The robus

Vinyl-Stilbene Compounds and Uses Thereof

The present invention relates to a biphenyl - stilbene (Vinyl-stilbene) - based compound and a pharmaceutical composition for preventing or treating norovirus infection comprising the same as an active ingredient. The present invention can be usefully used as a pharmaceutical composition for treating norovirus infection by showing superior norovirus inhibitory activity and lower cell toxicity as compared to previously known compounds.

Anti-oligomerization sheet molecules: Design, synthesis and evaluation of inhibitory activities against α-synuclein aggregation

Aggregation of α-synuclein (α-Syn) play a key role in the development of Parkinson Disease (PD). One of the effective approaches is to stabilize the native, monomeric protein with suitable molecule ligands. We have designed and synthesized a series of sheet-like conjugated compounds which possess different skeletons and various heteroatoms in the two blocks located at both ends of linker, which have good π-electron delocalization and high ability of hydrogen-bond formation. They have shown anti-aggregation activities in vitro towards α-Syn with IC50 down to 1.09 μM. The molecule is found binding in parallel to the NACore within NAC domain of α-Syn, interfering aggregation of NAC region within different α-Syn monomer, and further inhibiting or slowing down the formation of α-Syn oligomer nuclei at lag phase. The potential inhibitor obtained by our strategy is considered to be highly efficient to inhibit α-Syn aggregation.

HISTONE DEACETYLASE INHIBITORS

Provided herein are compounds and methods for inhibiting histone deacetylase ("HDAC") enzymes (e.g., HDAC1, HDAC2, and HDAC3).