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1253055-99-0

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1253055-99-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1253055-99-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,3,0,5 and 5 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1253055-99:
(9*1)+(8*2)+(7*5)+(6*3)+(5*0)+(4*5)+(3*5)+(2*9)+(1*9)=140
140 % 10 = 0
So 1253055-99-0 is a valid CAS Registry Number.

1253055-99-0Downstream Products

1253055-99-0Relevant articles and documents

Two methods for the preparation of sitagliptin phosphate: Via chemical resolution and asymmetric hydrogenation

Ye, Fei,Zhang, Zhifeng,Zhao, Wenxia,Ding, Jianhai,Wang, Yali,Dang, Xueyan

, p. 4805 - 4809 (2021)

Two effective processes have been developed for the preparation of sitagliptin phosphate. The approach of chemical resolution obtained R-sitagliptin in five steps from commercially available starting materials using the inexpensive NaBH4 to reduce the enamine and then using (-)-di-p-toluoyl-l-tartaric acid to resolve racemates in 11% yield overall. The route successfully avoids the use of expensive noble metal as catalysts compared with traditional synthesis methods, resulting in greatly reduced costs and simplified synthetic routes. Other alternative asymmetric hydrogenation of β-ketomide routes for the synthesis of sitagliptin were found, two of the intermediates were synthesized for the first time. This journal is

PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS INTERMEDIATES

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Page/Page column 49, (2010/11/05)

The present invention relates to novel and improved processes for the preparation of Sitagliptin compound of formula (1) and its intermediates.

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