1253691-83-6Relevant articles and documents
Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives
Wang, Lisheng,You, Yejun,Wang, Songqing,Liu, Xu,Liu, Buming,Wang, Jinni,Lin, Xiao,Chen, Mingsheng,Liang, Gang,Yang, Hua
supporting information; experimental part, p. 4100 - 4102 (2012/07/14)
Nineteen previously unreported matrine derivatives were synthesized and characterized using elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and mass spectrometry. Target compounds 6a-6l and 7a-7c showed stronger inhibitory activities than matrine in the in vitro antitumor tests and inhibited the growth of the Hep7402, B16-F10, A549, and TW03 cell lines. In addition, compound 6i exhibited a potent antitumor activity similar to that of colchicine.
