125376-03-6Relevant articles and documents
A subtype-selective, use-dependent inhibitor of native AMPA receptors
Nilsen, Aaron,England, Pamela M.
, p. 4902 - 4903 (2008/02/03)
AMPA (α-amino-3-hydroxy-5-methyl-4-isooxazole) receptors (AMPARs) are glutamate-gated ion channels that play central roles in the mammalian brain, mediating fast excitatory synaptic transmission and underlying several forms of synaptic plasticity. Two sub
Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same
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, (2008/06/13)
The present invention provides a compound having the structure: STR1 wherein R1 is hydrogen or a branched or unbranched, substituted or unsubstituted aminoalkyl having from two to twenty atoms in the chain, R2 is hydrogen, methyl, or a branched or unbranched, substituted or unsubstituted alkyl having from two to twenty atoms in the chain; when R2 is methyl, R3 is either hydrogen or a substituted or unsubstituted aryl; and R4 is methyl, a branched or unbranched, substituted or unsubstituted alkyl, alkenyl, alkynyl, alkenynyl, or cycloalkyl having from two to twenty atoms in the chain, or a substituted or unsubstituted aryl group. The invention also concerns a method of preparing the compound from the venom, venom sacs or venom glands of the wasp Philanthus triangulun F. Additionally, the invention provides a method of chemically synthesizing the compound. Another aspect of the invention concerns a method of treating a subject afflicted by a disorder associated with binding of an etiological agent to a glutamate receptor. Lastly, the invention provides an insecticidal composition which comprises an effective amount of the compound and a suitable carrier and a method of combatting insects which comprises administering to the insects the insecticidal composition.
Synthesis of glutamate receptor antagonist philanthotoxin-433 (PhTX-433) and its analogs
Goodnow Jr.,Konno,Niwa,Kallimopoulos,Bukownik,Lenares,Nakanishi
, p. 3267 - 3286 (2007/10/02)
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