125520-62-9

Basic information

• Product Name: 4-Phenyl-3-furoxancarbonitrile
• Synonyms: Furoxan, RVC-589;Phenyl-furazancarbonitrile 2-Oxide
• CAS NO: 125520-62-9
• Molecular Formula: C₉H₅N₃O₂
• Molecular Weight: 187.158
• Product Categories: Nitric Oxide Reagents
• Mol File: 125520-62-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 73-74°C
• Boiling Point: 415.3±47.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• PKA: -0.84±0.39(Predicted)
• CAS DataBase Reference: 4-Phenyl-3-furoxancarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Phenyl-3-furoxancarbonitrile(125520-62-9)
• EPA Substance Registry System: 4-Phenyl-3-furoxancarbonitrile(125520-62-9)

Safety Data

• Hazardous Substances Data: 125520-62-9(Hazardous Substances Data)

Usage

Chemical Properties

Crystalline Solid

Uses

Different sources of media describe the Uses of 125520-62-9 differently. You can refer to the following data:
1. Able to activate the soluble guanylate cyclase by releasing Nitric Oxide under the action of thiol cofactors. Also inhibits platelet aggregation
2. Able to activate the soluble guanylate cyclase by releasing Nitric Oxide under the action of thiol cofactors. Also inhibits platelet aggregation.

InChI:InChI=1/C9H6N3O2/c10-6-8-9(11-14-12(8)13)7-4-2-1-3-5-7/h1-5,13H

Upstream product

• 125520-63-0 3-phenyl-4-cyano-furoxan 
• 125520-59-4 4-phenyl-3-furoxancarboxamide 
• 6898-86-8 3-methyl-4-phenylfuroxan 
• 169614-78-2 3-(bromomethyl)-2-oxido-4-phenyl-1,2,5-oxadiazole 
• 135733-30-1 3-(hydroxymethyl)-4-phenylfuroxan 
• 125520-58-3 methyl 4-phenyl-3-furoxancarboxylate 
• 157066-36-9 2-Oxy-4-phenyl-furazan-3-carbonyl chloride 
• 125520-55-0 3-carboxy-4-phenyl-1,2,5-oxadiazole 2-oxide 
• 125520-54-9 4-hydroxyimino-3-phenyl-5(4H)-isoxazolone 
• 135733-34-5 4-phenylfuroxan-3-carboxaldehyde 
• 151733-56-1 4-phenyl-3-furoxanylcarbaldehyde oxime 

Downstream Products

• 125520-63-0 3-phenyl-4-cyano-furoxan 
• 857820-75-8 4-phenyl-furazan-3-carbonitrile 
• 77037-01-5 5-amino-3-phenyl-4-(phenylthio)isoxazole 

Relevant articles and documents

An efficient access to (1H-tetrazol-5-yl)furoxan ammonium salts via a two-step dehydration/[3+2]-cycloaddition strategy

A general, highly effective two-step approach for direct synthesis of (1H-tetrazol-5-yl)furoxan ammonium salts with various functional substituents based on initial effective synthesis of cyanofuroxans by dehydration of furoxancarboxylic acid amides by th

Synthesis of furoxan derivatives: DABCO-mediated cascade sulfonylation/cyclization reaction of α-nitro-ketoximes

A convenient and efficient method for the synthesis of furoxan derivatives from α-nitro-ketoximes and sulfonyl chlorides is reported. A wide variety of furoxan derivatives were smoothly obtained in good yields via a DABCO-mediated cascade sulfonylation/cy

1,2,5-Oxadiazole N-oxide derivatives as potential anti-cancer agents: Synthesis and biological evaluation. Part IV

Several new 1,2,5-oxadiazole N-oxide derivatives and some deoxygenated analogues were synthesized to be tested as potential selective hypoxic cell cytotoxins. Compounds prepared were designed in order to gain insight into the mechanism of action of this kind of cytotoxin. Compounds were tested in oxia and hypoxia and they proved to be non-selective. 3-Cyano-N2-oxide-4-phenyl-1,2,5-oxadiazole showed the best cytotoxic activity in oxia. The cytotoxicity observed for these derivatives could be explained in terms of the electronic characteristics of the 1,2,5-oxadiazole substituents. Electrochemical and ESR studies were performed on the more cytotoxic derivative.