1256379-85-7Relevant articles and documents
Transfer of Sequence Information and Replication of Diimine Duplexes
Strom, Kyle R.,Szostak, Jack W.,Prywes, Noam
, p. 3754 - 3761 (2019)
The ability of the biopolymers RNA and DNA to store and transfer information is essential to life. Herein, we demonstrate template-directed replication in a set of dimer duplexes that use reversible covalent bonds to form base-pairing interactions. Binary sequence information was encoded as a sequence of aniline and benzaldehyde subunits linked together by a diethynyl benzene backbone. These dimers formed sequence-specific, imine-linked duplexes, which could be separated and used as templates for the synthesis of daughter duplexes with identical sequences.