1256584-77-6

Basic information

• Product Name: Alectinib Intermediates
• Synonyms: tert-butyl 6-cyano-2-(2-(4-ethyl-3-(4-morpholinopiperidin-1-yl)phenyl)propan-2-yl)-1H-indole-3-carboxylate
• CAS NO: 1256584-77-6
• Molecular Formula: C34H45ClN4O3
• Molecular Weight: 593.21
• Mol File: 1256584-77-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Alectinib Intermediates(CAS DataBase Reference)
• NIST Chemistry Reference: Alectinib Intermediates(1256584-77-6)
• EPA Substance Registry System: Alectinib Intermediates(1256584-77-6)

Safety Data

• Hazardous Substances Data: 1256584-77-6(Hazardous Substances Data)

Usage

Description

Tert-butyl 6-cyano-2-[2-[4-ethyl-3-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propan-2-yl]-1H-indole-3-carboxylate;hydrochloride is a complex organic compound that serves as an intermediate in the synthesis of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor. Tert-butyl 6-cyano-2-[2-[4-ethyl-3-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propan-2-yl]-1H-indole-3-carboxylate;hydrochloride plays a crucial role in the development of pharmaceuticals targeting specific cancer-related mutations.

Uses

Used in Pharmaceutical Industry:
Tert-butyl 6-cyano-2-[2-[4-ethyl-3-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propan-2-yl]-1H-indole-3-carboxylate;hydrochloride is used as a key intermediate in the synthesis of Alectinib, a medication for the treatment of anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer (NSCLC). Its role is to help create a highly selective and potent ALK inhibitor that can effectively block the resistant gatekeeper mutant, leading to a reduction in tumor cell growth.