125697-93-0 Usage
Description
Lavendustin C, derived from a Streptomyces griseolavendus butyl acetate extract, is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase. It is characterized by its brown solid appearance and exhibits significant inhibitory activity against various kinases, including pp60c-src(+) kinase and Ca2+ calmodulin-dependent kinase II.
Uses
LAVENDUSTIN C is used as a potent tyrosine kinase inhibitor for its ability to inhibit EGF receptor-associated tyrosine kinase, pp60c-src(+) kinase, and Ca2+ calmodulin-dependent kinase II, making it a valuable compound in the field of cancer research and treatment.
Used in Pharmaceutical Industry:
LAVENDUSTIN C is used as an anticancer agent for its potent tyrosine kinase inhibitory activity, which can potentially be applied in the development of targeted therapies against various types of cancer.
Used in Research Applications:
LAVENDUSTIN C is used as a research tool for studying the roles and mechanisms of tyrosine kinases in cellular processes, as well as for identifying potential therapeutic targets in cancer and other diseases related to kinase dysregulation.
Check Digit Verification of cas no
The CAS Registry Mumber 125697-93-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,6,9 and 7 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 125697-93:
(8*1)+(7*2)+(6*5)+(5*6)+(4*9)+(3*7)+(2*9)+(1*3)=160
160 % 10 = 0
So 125697-93-0 is a valid CAS Registry Number.
InChI:InChI=1/C14H13NO5/c16-10-2-4-12(17)8(5-10)7-15-9-1-3-13(18)11(6-9)14(19)20/h1-6,15-18H,7H2,(H,19,20)
125697-93-0Relevant articles and documents
A versatile solid phase synthesis of lavendustin A and certain biologically active analogs
Devraj, Rajesh,Cushman, Mark
, p. 9368 - 9373 (1996)
Reaction of aminomethylated polystyrene resin (8) with succinic anhydride, followed by esterification of the free carboxylic acid of the product 9 with 2,5-dihydroxybenzaldehyde (4), afforded the resin-linked aldehyde intermediate 10. The key intermediate 10 was converted into the protein-tyrosine kinase inhibitor lavendustin A and certain analogs through reductive amination and reductive alkylation steps, followed by cleavage from the resin. This method enables the preparation of a wide variety of lavendustin A analogs using combinatorial chemistry and parallel synthesis techniques.
Novel antiproliferative agents derived from lavendustin A
Nussbaumer,Winiski,Cammisuli,Hiestand,Weckbecker,Stutz
, p. 4079 - 4084 (2007/10/02)
The active partial structure of the potent tyrosine kinase inhibitor lavendustin A was derivatized in the search for novel agents against cellular proliferation. The antiproliferative potential of the new derivatives was determined using the human keratin
