125712-82-5

Basic information

• Product Name: (S)-1-(3-Nitrophenyl)propanol
• Synonyms: (S)1-(3-NITROPHENYL)PROPANOL
• CAS NO: 125712-82-5
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.19
• Mol File: 125712-82-5.mol
• Article Data: 105

Chemical Properties

• Boiling Point: 295.307 °C at 760 mmHg
• Flash Point: 127.842 °C
• Appearance: /
• Density: 1.217 g/cm³
• CAS DataBase Reference: (S)-1-(3-Nitrophenyl)propanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(3-Nitrophenyl)propanol(125712-82-5)
• EPA Substance Registry System: (S)-1-(3-Nitrophenyl)propanol(125712-82-5)

Safety Data

• Hazardous Substances Data: 125712-82-5(Hazardous Substances Data)

Usage

General Description

(S)-1-(3-Nitrophenyl)propanol is a specific chemical compound with a molecular structure consisting of a propanol group attached to a 3-nitrophenyl group. It is commonly used in the synthesis of pharmaceuticals, agrochemicals, and perfumes. (S)-1-(3-Nitrophenyl)propanol is known for its ability to function as a chiral building block, meaning it can be used in the production of other chiral compounds. It is also known for its aromatic properties due to the presence of the 3-nitrophenyl group, making it useful in the manufacturing of fragrances and scents. Additionally, (S)-1-(3-Nitrophenyl)propanol has been investigated for its potential as an antiviral and antibacterial agent, making it of interest in the field of medicine and drug development.

Upstream product

• 936-59-4 3-chloropropiophenone 
• 141987-54-4 1-Phenyl-3-chlor-propyl-monochloracetat 
• 108-05-4 vinyl acetate 
• 18776-12-0 3-chloro-1-phenyl-propan-1-ol 
• 22912-90-9 (RS)-3-chloro-1-phenyl-1-propyl acetate 
• 97-72-3 2-Methylpropionic anhydride 
• 108-22-5 Isopropenyl acetate 
• 293322-40-4 3-Cloro-1-phenylpropyl butanoate 
• 34841-35-5 3'-chloro-propiophenone 
• 111-42-2 2,2'-iminobis[ethanol] 
• 123-20-6 vinyl n-butyrate 
• 142037-19-2 Chloro-acetic acid (S)-3-chloro-1-phenyl-propyl ester 
• 871351-43-8 methanesulfonic acid 3-chloro-1-phenyl-propyl ester 
• 71-43-2 benzene 

Downstream Products

• 22165-02-2 1-Phenyl-3-chlor-propyl-diethylaminomethyl-ether 
• 22216-19-9 3-Mercapto-1-phenyl-propanol-⁽¹⁾ 
• 22165-45-3 1-Phenyl-3-chlor-propyl-butyloxymethylether 
• 22165-42-0 1-Phenyl-3-chlor-propyl-ethoxymethylether 
• 22165-04-4 1-Phenyl-3-chlor-propyl-n-butylether 
• 5650-41-9 3-hydroxy-1-phenylpropan-1-one 
• 23518-28-7 1-Phenyl-3-chlor-propyl-(β-hydroxy-ethyl)-ether 
• 22165-41-9 1-Phenyl-3-chlor-propyl-methoxymethyl-ether 
• 22216-17-7 1-Phenyl-3-phenoxy-propanol-⁽¹⁾ 
• 62296-03-1 rac-3-acetoxy-1-phenylpropan-1-ol 
• 22165-48-6 1-Phenyl-3-chlor-propyl-isopentyloxymethyl-ether 
• 22165-46-4 1-Phenyl-3-chlor-propyl-isobutyloxymethylether 
• 22165-44-2 1-Phenyl-3-chlor-propyl-isopropyloxymethylether 
• 22165-43-1 1-Phenyl-3-chlor-propyl-propoxymethylether 

Relevant articles and documents

Synthesis and in silico evaluation of novel compounds for PET-based investigations of the norepinephrine transporter

Since the norepinephrine transporter (NET) is involved in a variety of diseases, the investigation of underlying dysregulation-mechanisms of the norepinephrine (NE) system is of major interest. Based on the previously described highly potent and selective NET ligand 1-(3-(methylamino)-1-phenylpropyl)-3-phenyl-1,3-dihydro-2H-benzimidaz- ol-2-one (Me@APPI), this paper aims at the development of several fluorinated methylaminebased analogs of this compound. The newly synthesized compounds were computationally evaluated for their interactions with the monoamine transporters and represent reference compounds for PET-based investigation of the NET.

Asymmetric hydrogenation of 3-chloro-1-phenylpropan-1-one catalyzed by ruthenium complexes

Abstract A ruthenium complex modified with (1S,2S)-1,2-diphenyl-1,2-ethanediamine efficiently catalyzes asymmetric hydrogenation of 3-chloro-1-phenylpropan-1-one in the presence of potassium hydroxide solution in isopropyl alcohol, specific optical rotation of the synthesized products reaching -24.6°. Effects of the reaction time, hydrogen pressure, and the alkali concentration on the reaction course have been elucidated.

Preparation method of cefamoxetine hydrochloride

The invention discloses a preparation method of tamoxidectin hydrochloride, belongs to the technical field of drug synthesis, and uses 3 - chlorine -1 - phenylpropanone as a raw material to undergo a reduction reaction. The synthesis route has the advantages of few reaction steps, mild reaction conditions,3 - simple 2 - operation, cheap -3 - and easily available raw materials, and low production cost 3 - and -1 - R-chloro - N - phenylpropanone is used as a raw material.

Total Synthesis of Meayamycin B

Meayamycin B is currently the most potent modulator of the splicing factor 3b subunit 1 and used by dozens of research groups. However, current supply for this natural product analogue is limited because of the lengthy synthetic scheme. Here, we report a more concise, more cost-effective, and greener synthesis of this compound by developing and employing a novel asymmetric reduction of a prochiral enone to afford an allylic alcohol with high enantioselectivity. In addition to this reaction, this synthesis highlights a scalable Mukaiyama aldol reaction, Nicolaou-type epoxide opening reaction, stereoselective Corey-Chaykovsky-type reaction, and a modified Horner-Wadsworth-Emmons Z-selective olefination. We also discuss a Z-E isomerization during the α,β-unsaturated amide formation. The new synthesis of meayamycin B consists of 11 steps in the longest linear sequence and 24 total steps.

Naphthyl-derived orthometalated RUII-NHC complexes: Effect of the NHC donors and/or substitution pattern on their synthesis and catalytic activity

Naphthyl-derived orthometalated RuII-NHC complexes have been developed for catalytic applications considering the stereoelectronic profiles of the NHC ligands, which can be modified easily via alteration of the NHC donors (ImNHC/1,2,4tzNHC) as well as their substitution pattern at the naphthyl ring. The azolium salts [(2a?c)-H]Br, precursors for the NHC ligands, react with [Ru(p-cymene)Cl2]2 in the presence of a base to deliver the ortho-metalated RuII-NHC complexes 3a?c with the general formula [(NHC)Ru(p-cymene)Br]. Orthometalation in these complexes can be exploited for further functionalization of the NHC ligands. This is depicted by the generation of the diphenylethylene-inserted isolable intermediate complex 4, from the reaction of 3a with diphenylacetylene in a 1:1 ratio, which eventually provides an annulated salt 5a-Br via reductive elimination. Gratifyingly, this process can also be made catalytic, which directly provides several mono-/bis-annulated cationic N-heterocyclic compounds starting from the imidazolium salts [(2a,b)-H]Br using [Ru(p-cymene)Cl2]2 as a precatalyst. Furthermore, subtle variations in the electronic profiles of the complexes 3a?c in combination with steric alterations are observed to influence their activity in the transfer hydrogenation of acetophenone, a model for the hydride transfer process. Among all the complexes studied here, complex 3b with an ImNHC donor at the second position of the naphthyl ring was identified as a superior catalyst in comparison to 3a,c featuring either a different NHC donor or substitution pattern with a low loading of 0.1 mol%.