1257335-48-0

Basic information

• Product Name: (E)-N-hydroxy-3-(1-(3-(3-methoxyphenyl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)acrylamide
• Synonyms: (E)-N-hydroxy-3-(1-(3-(3-methoxyphenyl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)acrylamide
• CAS NO: 1257335-48-0
• Molecular Weight: 328.368
• Mol File: 1257335-48-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-N-hydroxy-3-(1-(3-(3-methoxyphenyl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)acrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-hydroxy-3-(1-(3-(3-methoxyphenyl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)acrylamide(1257335-48-0)
• EPA Substance Registry System: (E)-N-hydroxy-3-(1-(3-(3-methoxyphenyl)propyl)-2-oxo-1,2-dihydropyridin-3-yl)acrylamide(1257335-48-0)

Safety Data

• Hazardous Substances Data: 1257335-48-0(Hazardous Substances Data)

Upstream product

• 6943-97-1 (m-methoxyphenyl)propyl bromide 
• 36404-89-4 2-oxo-1,2-dihydro-pyridine-3-carbaldehyde 

Relevant articles and documents

Improving potency and metabolic stability by introducing an alkenyl linker to pyridine-based histone deacetylase inhibitors for orally available RUNX3 modulators

RUNX3, a tumor suppressor, is suppressed in various cancers by abnormal epigenetic changes. Histone deacetylases (HDACs) can deacetylate the lysine residues of RUNX3, followed by degradation via a ubiquitin-mediated pathway. Inhibition of HDAC leads to functional restoration of the RUNX3 protein by epigenetic expression and RUNX3 protein stabilization. We previously reported a series of HDAC inhibitors that restored RUNX3 function. In the present study, we introduced an alkenyl linker group to pyridine-based HDAC inhibitors to improve their potencies and chemical properties. This alkenyl linker made the compounds more rigid, facilitating a better fit than alkyl moieties to the active site of HDAC proteins. Most compounds in this series exhibited potent RUNX activities, HDAC inhibitory activities, and inhibitory activities towards the growth of human cancer cell lines. Notably, one of these derivatives, (E)-3-(1-cinnamyl-2-oxo-1,2-dihydropyridin-3-yl)-N-hydroxyacrylamide (7k), showed excellent properties in a microsomal stability study, in a xenograft study, and in an in vivo pharmacokinetic evaluation. Modulation of RUNX3 therefore results in highly potent and orally available anticancer chemotherapeutic agents.