1257856-15-7

Basic information

• Product Name: (S)-N-Boc-2-(2-hydroxyethyl)morpholine
• Synonyms: (S)-N-Boc-2-(2-hydroxyethyl)morpholine;(2S)-2-(2-Hydroxyethyl)-4-morpholinecarboxylic acid tert-butyl ester;(S)-tert-butyl 2-(2-hydroxyethyl)morpholine-4-carboxylate
• CAS NO: 1257856-15-7
• Molecular Formula: C11H21NO4
• Molecular Weight: 231
• Mol File: 1257856-15-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 336℃
• Flash Point: 157℃
• Appearance: /
• Density: 1.097
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-N-Boc-2-(2-hydroxyethyl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-Boc-2-(2-hydroxyethyl)morpholine(1257856-15-7)
• EPA Substance Registry System: (S)-N-Boc-2-(2-hydroxyethyl)morpholine(1257856-15-7)

Safety Data

• Hazardous Substances Data: 1257856-15-7(Hazardous Substances Data)

Usage

General Description

"(S)-N-Boc-2-(2-hydroxyethyl)morpholine" is a chemical compound often used in medicinal chemistry and organic synthesis. Its systematic name is tert-butyl (2-((S)-morpholin-2-yl)ethyl)carbamate. The compound usually comes as a white powder or colorless liquid, and it has a molecular formula of C12H23NO4. This specific chemical is known as a chiral compound, meaning it has a unique 3D arrangement of atoms that cannot be superimposed on its mirror image. This aspect can be particularly important in applications such as drug development where the 3D structure can influence a drug’s effectiveness and interactions within the body.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 132995-76-7 (2-hydroxyethyl)-morpholine 
• 112887-43-1 2-(2-hydroxyethyl)-4-benzylmorpholine 
• 503601-25-0 (±)-ethyl 2-(morpholin-2-yl)acetate 
• 73933-19-4 ethyl 4-(phenylmethyl)-2-morpholineacetate 
• 766539-28-0 2-(4-(tert-butoxycarbonyl)morpholin-2-yl)acetic acid 

Downstream Products

• 1289142-23-9 C₃₈H₄₄FN₃O₇ 
• 1217340-02-7 2-(4-fluorophenyl)-5-(5-(isobutylcarbamoyl)-2-(2-(morpholin-2-yl)ethoxy)phenyl)-N-methylbenzofuran-3-carboxamide trifluoroacetate 
• 1033219-23-6 WYE-114152 
• 1033219-19-0 1-(3-methoxyphenyl)-3-{2-[(2R)-morpholin-2-yl]ethyl}-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 1033219-02-1 1-(4-fluorophenyl)-3-{2-[(2R)-morpholin-2-yl]ethyl}-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 1033219-08-7 1-(2,4-difluorophenyl)-3-{2-[(2R)-morpholin-2-yl]ethyl}-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 1033219-15-6 1-{2-[(2R)-morpholin-2-yl]ethyl}-3-(2,4,6-trifluorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 1334315-81-9 4-fluoro-1-(2-fluorophenyl)-3-(2-morpholin-2-ylethyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 1334315-83-1 5-fluoro-1-(2-fluorophenyl)-3-(2-morpholin-2-ylethyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 1334315-86-4 5-fluoro-3-(2-fluorophenyl)-1-(2-morpholin-2-ylethyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 1334315-89-7 4-fluoro-3-(2-fluorophenyl)-1-(2-morpholin-2-ylethyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 1033218-92-6 1-(2-morpholin-2-ylethyl)-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 1033218-96-0 1-{2-[(2R)-morpholin-2-yl]ethyl}-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 1033218-94-8 1-{2-[(2S)-morpholin-2-yl]ethyl}-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 

Relevant articles and documents

PYRIDYL DERIVATIVES AS BROMODOMAIN INHIBITORS

The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

SUBSTITUTED MORPHOLINES AS MODULATORS FOR THE CALCIUM SENSING RECEPTOR

Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors of Formula (I).

Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152)

Sequential modification of the previously identified 4-[3-aryl-2,2-dioxido- 2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols led to the identification of a new series of 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro- 2,1,3-benzothiadiazole 2,2-dioxides that are potent and selective inhibitors of the norepinephrine transporter over both the serotonin and dopamine transporters. One representative compound 10b (WYE-114152) had low nanomolar hNET potency (IC50 = 15 nM) and good selectivity for hNET over hSERT (>430-fold) and hDAT (>548-fold). 10b was additionally bioavailable following oral dosing and demonstrated efficacy in rat models of acute, inflammatory, and neuropathic pain.