125829-10-9

Basic information

• Product Name: di-(3-amino-1-propyl)disulfide dihydrochloride
• Synonyms: di-(3-amino-1-propyl)disulfide dihydrochloride
• CAS NO: 125829-10-9
• Molecular Weight: 253.26
• Mol File: 125829-10-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: di-(3-amino-1-propyl)disulfide dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: di-(3-amino-1-propyl)disulfide dihydrochloride(125829-10-9)
• EPA Substance Registry System: di-(3-amino-1-propyl)disulfide dihydrochloride(125829-10-9)

Safety Data

• Hazardous Substances Data: 125829-10-9(Hazardous Substances Data)

Upstream product

• 5554-48-3 Tetrahydro-1,3-thiazin-2-thion 

Relevant articles and documents

Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors

Selective inhibition of KDAC isoforms while maintaining potency remains a challenge. Using the largazole macrocyclic depsipeptide structure as a starting point for developing new KDACIs with increased selectivity, a combination of four different simplified largazole analogue (SLA) scaffolds with diverse zinc-binding groups (for a total of 60 compounds) were designed, synthesized, and evaluated against class I KDACs 1, 3, and 8, and class II KDAC6. Experimental evidence as well as molecular docking poses converged to establish the cyclic tetrapeptides (CTPs) as the primary determinant of both potency and selectivity by influencing the correct alignment of the zinc-binding group in the KDAC active site, providing a further basis for developing new KDACIs of higher isoform selectivity and potency.