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1259391-05-3

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1259391-05-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1259391-05-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,9,3,9 and 1 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1259391-05:
(9*1)+(8*2)+(7*5)+(6*9)+(5*3)+(4*9)+(3*1)+(2*0)+(1*5)=173
173 % 10 = 3
So 1259391-05-3 is a valid CAS Registry Number.

1259391-05-3Relevant articles and documents

Design and synthesis of a series of α-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility

Ohashi, Masao,Oyama, Takuji,Putranto, Endy Widya,Waku, Tsuyoshi,Nobusada, Hiromi,Kataoka, Ken,Matsuno, Kenji,Yashiro, Masakazu,Morikawa, Kosuke,Huh, Nam-Ho,Miyachi, Hiroyuki

, p. 2319 - 2332 (2013/05/09)

In the continuing study directed toward the development of peroxisome proliferator-activated receptor gamma (hPPARγ) agonist, we attempted to improve the water solubility of our previously developed hPPARγ-selective agonist 3, which is insufficiently soluble for practical use, by employing two strategies: introducing substituents to reduce its molecular planarity and decreasing its hydrophobicity via replacement of the adamantyl group with a heteroaromatic ring. The first approach proved ineffective, but the second was productive. Here, we report the design and synthesis of a series of α-benzyl phenylpropanoic acid-type hPPARγ partial agonists with improved aqueous solubility. Among them, we selected (R)-7j, which activates hPPARγ to the extent of about 65% of the maximum observed with a full agonist, for further evaluation. The ligand-binding mode and the reason for the partial-agonistic activity are discussed based on X-ray-determined structure of the complex of hPPARγ ligand-binding domain (LBD) and (R)-7j with previously reported ligand-LDB structures. Preliminal apoptotic effect of (R)-7j against human scirrhous gastric cancer cell line OCUM-2MD3 is also described.

Design, synthesis, and structural analysis of phenylpropanoic acid-type PPARγ-selective agonists: Discovery of reversed stereochemistry-activity relationship

Ohashi, Masao,Oyama, Takuji,Nakagome, Izumi,Satoh, Mayumi,Nishio, Yoshino,Nobusada, Hiromi,Hirono, Shuichi,Morikawa, Kosuke,Hashimoto, Yuichi,Miyachi, Hiroyuki

, p. 331 - 341 (2011/03/22)

Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-mediated transcription factor with roles in glucose, lipid, and lipoprotein homeostasis, and PPARγ ligands are expected have therapeutic potential in these as well as other areas. We rep

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