126-52-3 Usage
Originator
Valmid,Dista,US,1955
Definition
ChEBI: A carbamate ester that is the 1-vinylcyclohexyl ester of carbamic acid. A short-acting sedative-hypnotic, it was formerly used to treat insomnia.
Manufacturing Process
A solution of 34 cc (0.5 mol) of liquid phosgene in 150 cc of absolute ether is
reacted while cooling with a mixture of sodium chloride and ice, first with 62
grams (0.5 mol) of 1-ethinyl cyclohexanol-1 and then with 64 cc (0.5 mol) of
quinoline. The precipitated quinoline chlorohydrate is filtered off and the
filtrate is reacted with ammonia in ether. In this manner 45 grams of the
carbamic acid ester of 1-ethinyl cyclohexanol are obtained. Yield: 53% of the
theoretical yield. The ester boils at 108° to 110°C/3 mm and on
recrystallization from cyclohexane, yields colorless needles melting at 94° to
96°C.
Therapeutic Function
Sedative
Safety Profile
A deadly human
poison. Experimental poison by ingestion,
intravenous, subcutaneous, and
intraperitoneal routes. An experimental
teratogen. When heated to decomposition it
emits toxic fumes of NOx. See also
CARBAMATES.
Check Digit Verification of cas no
The CAS Registry Mumber 126-52-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 6 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 126-52:
(5*1)+(4*2)+(3*6)+(2*5)+(1*2)=43
43 % 10 = 3
So 126-52-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H13NO2/c1-2-9(12-8(10)11)6-4-3-5-7-9/h1H,3-7H2,(H2,10,11)
126-52-3Relevant articles and documents
Carbonylation of propargyl carbamates with palladium(II) bisoxazoline catalysts: Efficient synthesis of 5-methoxy-3(2H)-furanones
Kusakabe, Taichi,Takahashi, Takeo,Shen, Rong,Ikeda, Ayumi,Dhage, Yogesh Daulat,Kanno, Yuichro,Inouye, Yoshio,Sasai, Hiroaki,Mochida, Tomoyuki,Kato, Keisuke
, p. 7845 - 7849 (2013/08/23)
Palladium and CO: Carbonylation of 1 with [Pd(tfa)2(±)- L1] (tfa=trifluoroacetate) affords the spirofuranone 2 with inversion of the stereochemistry at C17 in 96 % yield. C17-epi-1 also gave the same product 2 with retention of the stereochemistry at C17. Labelling studies show that 13CO was incorporated into the C5′ position of the furanone ring. The first asymmetric version of this new reaction was achieved. Copyright
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