1260095-04-2

Basic information

• Product Name: {4-[6-(5-fluoro-2-methylphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]pyridin-3-yl}carbamic acid tert-butyl ester
• Synonyms: {4-[6-(5-fluoro-2-methylphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]pyridin-3-yl}carbamic acid tert-butyl ester
• CAS NO: 1260095-04-2
• Molecular Weight: 494.529
• Mol File: 1260095-04-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: {4-[6-(5-fluoro-2-methylphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]pyridin-3-yl}carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {4-[6-(5-fluoro-2-methylphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]pyridin-3-yl}carbamic acid tert-butyl ester(1260095-04-2)
• EPA Substance Registry System: {4-[6-(5-fluoro-2-methylphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]pyridin-3-yl}carbamic acid tert-butyl ester(1260095-04-2)

Safety Data

• Hazardous Substances Data: 1260095-04-2(Hazardous Substances Data)

Upstream product

• 1422-53-3 2-bromo-4-fluorotoluene 
• 400-31-7 1,1,1-trifluoro-4-methyl-pent-3-en-2-one 
• 2398-37-0 3-methoxyphenyl bromide 
• 849354-28-5 6-(5-fluoro-2-methylphenyl)-6-methyl-4-trifluoromethylhept-1-yn-4-ol 
• 154048-89-2 (4-iodo-pyridin-3-yl)-carbamic acid tert-butyl ester 

Downstream Products

• 609851-95-8 1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methyl-2-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)pentan-2-ol 

Relevant articles and documents

Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate

A series of nonsteroidal dissociated glucocorticoid receptor agonists was optimized for drug-like properties such as cytochrome P450 inhibition, metabolic stability, aqueous solubility, and hERG ion channel inhibition. This effort culminated in the identification of the clinical candidate compound (R)-39.