1260243-04-6

Basic information

• Product Name: Ethyl 5-aMino-1H-pyrazole-4-carboxylate
• Synonyms: 1H-Pyrazole-4-carboxylic acid, 3-amino-, ethyl ester; 1H-Pyrazole-4-carboxylic acid, 5-amino-, ethyl ester; Ethyl 3-amino-1H-pyrazole-4-carboxylate; Ethyl 5-amino-1H-pyrazole-4-carboxylate; Ethyl-5-amino-1H-pyrazol-4-carboxylat; 5-Amino-1H-pyrazole-4-carboxylic acid ethyl ester; Ethyl 5-Amino-1H-4-Pyrazolecarboxylate
• CAS NO: 1260243-04-6
• Molecular Formula: C₆H₉N₃O₂
• Molecular Weight: 155.15456
• EINECS: 230-262-3
• Mol File: 1260243-04-6.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 349.2°C at 760 mmHg
• Flash Point: 165°C
• Appearance: /
• Density: 1.318g/cm³
• Vapor Pressure: 4.79E-05mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: Ethyl 5-aMino-1H-pyrazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 5-aMino-1H-pyrazole-4-carboxylate(1260243-04-6)
• EPA Substance Registry System: Ethyl 5-aMino-1H-pyrazole-4-carboxylate(1260243-04-6)

Safety Data

• Hazardous Substances Data: 1260243-04-6(Hazardous Substances Data)

Usage

General Description

Ethyl 5-amino-1H-pyrazole-4-carboxylate is a chemical compound with a molecular formula of C7H10N3O2. This substance is categorized under the class of organic compounds known as pyrazoles, which are polycyclic aromatic compounds containing a five-membered ring with three carbon atoms and two nitrogen atoms. Ethyl 5-amino-1H-pyrazole-4-carboxylate appears as a light beige to brown crystalline powder at room temperature. Due to its properties, this chemical is commonly utilized in the field of organic synthesis, especially in the synthesis of pharmaceuticals. However, details regarding its safety profile and environmental impact are limited.

InChI:InChI=1/C6H9N3O2/c1-2-11-6(10)4-3-8-9-5(4)7/h3H,2H2,1H3,(H3,7,8,9)

Upstream product

• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 
• 42466-68-2 ethyl (Z)-2-cyano-3-methoxyacrylate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 105-56-6 ethyl 2-cyanoacetate 
• 72459-84-8 ethyl (ethoxymethylene)cyanoacetate 
• 94-05-3 2-cyano-3-ethoxyacrylic acid ethyl ester 

Downstream Products

• 78562-03-5 ethyl 7-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 78562-50-2 ethyl 7-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 116885-17-7 4-amino-8-ethoxycarbonyl-3-(p-chlorophenyl)amidinopyrazolo<5,1-c><1,2,4>triazine 
• 1116088-36-8 C₂₁H₁₈ClN₃O₂ 
• 1116088-38-0 C₂₁H₁₈ClN₃O₂ 
• 1116088-35-7 3-ethoxycarbonyl-5,7-diphenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine 
• 895764-31-5 ethyl 5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 931624-48-5 ethyl 6-(2-hydroxybenzoyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 73997-09-8 3,4-Dihydro-4-oxo-3-phenyl-pyrazolo<5,1-d>-1,2,3,5-tetrazin-8-carbonsaeure-ethylester 
• 1607024-08-7 ethyl 5-(4-chloro-3-methoxyphenyl)-7-oxo-4H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 1196153-97-5 ethyl 7-aminopyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 315-30-0 Allopurinol 
• 851772-84-4 ethyl 5-amino-1-(2-oxo-2-phenylethyl)-1Hpyrazole-4-carboxylate 
• 632365-91-4 6-bromo-7-cyclohexyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis and antiviral activity of sulfonohydrazide and 1,3,4-oxadiazole derivatives of 6,6-dimethyl-9-oxo-4,5,6,7,8,9-hexahydropyrazolo[5,1-b] quinazoline

A series of new 6,6-dimethyl-9-oxo-4,5,6,7,8,9-hexahydropyrazolo[5,1-b]quinazoline substituted benzenesulfonohydrazide and 1,3,4-oxadiazole derivatives has been synthesised and characterised using spectral techniques. The antiviral activity of these compounds against an avian paramyxovirus (APMV-1) has been screened and the results show that some of the compounds possess good antiviral activity.

An efficient synthesis of pyrazolo[1,5-a]pyrimidines and evaluation of their antimicrobial activity

A series of new pyrazolo[1,5-a]pyrimidine derivatives has been synthesized by using 7-hydrazinyl- 5-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile 1 and 7-amino-5-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile 2 as precursors. The pyrazolo[3,4-d] pyrimidines 3a–b have been synthesized by a three-step reaction starting with 1. Compound 1 was utilized for the synthesis of dioxopyrrolidindolinylamio-pyrazolo-pyrimidines 4a–b, and dioxoisoindolin-pyrazolo-pyrimidines 4c–d. Also, compounds 4a-dwere synthesized using deep eutectic solvents (DES). This method using DES provides several advantages such as benign environment, high yield, scalable and simple work-up procedure. Similarly, the cyclocondensation of 2 with α-acetyl- γ-butyrolactone afforded pyrazolo-pyrido-pyrimidine 5 and dihydrofuro-pyrido-pyrazolo-pyrimidine 6. All synthesized compounds were screened for antimicrobial activity. [Figure not available: see fulltext.]

Design, Synthesis, and Evaluation of the Anticancer Properties of a Novel Series of α-(Benzoylamino)-β-substituted Acrylic Amide Derivatives of Pyrazolo[1,5-a]pyrimidine

A novel series of α-(benzoylamino)-β-substituted acrylic amide derivatives of pyrazolo[1,5-a]pyrimidine has been synthesized using a convergent multistep synthesis. The synthesized compounds were characterized by 1H NMR, 13C NMR, ESI-MS, and IR analyses. Those new compounds were screened for their in vitro antiproliferative activity using an MTT assay analysis. Out of nine derivatives synthesized in the current study, compounds 13g, 13d, 13h, and 13i exhibited the greatest anticancer activities in HeLa and HepG2 cell lines. The in vitro anticancer activity of compound 13g against HeLa, HepG2, and MCF-7 cell lines is superior to the marketed drugs paclitaxel and SAHA.