1261066-10-7Relevant articles and documents
A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antioxidative Lamiaceae polyphenol
Fujimoto, Aya,Shingai, Yoshimi,Nakamura, Mitsuhiro,Maekawa, Tomomi,Sone, Yoshiaki,Masuda, Toshiya
, p. 7393 - 7396 (2010)
The iron-ion catalyzed oxidation of the ethanol solution of rosmarinic acid, a potent antioxidant polyphenol of Lamiaceae (Labiatae) plants, afforded a highly tyrosinase-inhibitory active product. The structure of the active product in the oxidation product mixture was determined using extensive NMR spectroscopy to have a novel oxygen-containing seven-membered ring system. The formation mechanism of the unique ring structure from the catechol part of the rosmarinic acid was proposed.