126225-89-6

Basic information

• Product Name: 1-(2-bromobenzyl)-3-methoxycarbonyl-1,4,5,6-tetrahydropyridine
• CAS NO: 126225-89-6
• Molecular Weight: 310.191
• Mol File: 126225-89-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-bromobenzyl)-3-methoxycarbonyl-1,4,5,6-tetrahydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromobenzyl)-3-methoxycarbonyl-1,4,5,6-tetrahydropyridine(126225-89-6)
• EPA Substance Registry System: 1-(2-bromobenzyl)-3-methoxycarbonyl-1,4,5,6-tetrahydropyridine(126225-89-6)

Safety Data

• Hazardous Substances Data: 126225-89-6(Hazardous Substances Data)

Upstream product

• 14997-05-8 methyl 1,4,5,6-tetrahydropyridine-3-carboxylate 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 

Downstream Products

• 75532-94-4 methyl 1-benzyl-1,4,5,6-tetrahydropyridine-3-carboxylate 
• 126225-76-1 rel-(8S,8aS)-8-methoxycarbonylperhydrobenzindolizine 
• 126225-76-1 rel-(8R,8aS)-8-methoxycarbonylperhydrobenzindolizine 

Relevant articles and documents

The Synthesis of Indolizidine and Quinolizidine Ring Systems by Free Radical Cyclization of 4-Aza-6-methoxycarbonyl-5-hexenyl Radicals

The formation of bicyclic amines by the intramolecular cyclization of 4-aza-6-methoxycarbonyl-5-hexenyl radicals is described.The direct attachment of a nitrogen atom to the double bond changes the electronic nature of the alkene such that the cyclization is less efficient than the all carbon analogue or the other aza-substituted 5-hexenyl cyclizations.The reaction has been used in a short, convenient synthesis of a variety of indolizidines from methyl nicotinate.In addition, the cyclization was used as the key step in a short synthesis of (+/-)-epilupinine from methyl nicotinate.