1263409-35-3

Basic information

• Product Name: C₃₁H₄₄BNO₇
• Synonyms: C₃₁H₄₄BNO₇
• CAS NO: 1263409-35-3
• Molecular Weight: 553.504
• Mol File: 1263409-35-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₁H₄₄BNO₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₁H₄₄BNO₇(1263409-35-3)
• EPA Substance Registry System: C₃₁H₄₄BNO₇(1263409-35-3)

Safety Data

• Hazardous Substances Data: 1263409-35-3(Hazardous Substances Data)

Upstream product

• 121554-10-7 5-bromo-2-iodobenzonitrile 
• 21740-00-1 5-bromo-2-iodo-benzoic acid 
• 1175526-42-7 {4'-bromo-2'-[(tert-butoxycarbonyl-ethyl-amino)-methyl]-6-methoxy-biphenyl-3-yl}-acetic acid ethyl ester 
• 73183-34-3 bis(pinacol)diborane 
• 1175526-43-8 (5-bromo-2-iodo-benzyl)-ethyl-carbamic acid tert-butyl ester 
• 1175525-90-2 (5-Bromo-2-iodo-benzyl)-ethyl-amine 

Relevant articles and documents

Sodium [2′-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4′-(6- ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): A potent, selective prostaglandin D2 receptor antagonist

Compound 21 (AM432) was identified as a potent and selective antagonist of the DP2 receptor (CRTH2). Modification of a bi-aryl core identified a series of tri-aryl antagonists of which compound 21 proved a viable clinical candidate. AM432 shows excellent potency in a human whole blood eosinophil shape change assay with prolonged incubation, a comparatively long off-rate from the DP2 receptor, excellent pharmacokinetics in dog and in vivo activity in two mouse models of inflammatory disease after oral dosing.