1264272-63-0Relevant articles and documents
Fluorescent mimics of cholesterol that rapidly bind surfaces of living mammalian cells
Hymel, David,Cai, Sutang,Sun, Qi,Henkhaus, Rebecca S.,Perera, Chamani,Peterson, Blake R.
, p. 14624 - 14627 (2015)
Mammalian cells acquire cholesterol, a critical membrane constituent, through multiple mechanisms. We synthesized mimics of cholesterol, fluorescent N-alkyl-3β-cholesterylamine-glutamic acids, that are rapidly incorporated into cellular plasma membranes compared with analogous cholesteryl amides, ethers, esters, carbamates, and a sitosterol analogue. This process was inhibited by ezetimibe, indicating a receptor-mediated uptake pathway.