126802-52-6

Basic information

• Product Name: 2-Methyl-2-(2-nitrophenyl)propanoicacid
• Synonyms: 2-Methyl-2-(2-nitrophenyl)propanoicacid
• CAS NO: 126802-52-6
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.19864
• Mol File: 126802-52-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 146-148 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 363.1°C at 760 mmHg
• Flash Point: 157.7°C
• Appearance: /
• Density: 1.286g/cm³
• Vapor Pressure: 6.58E-06mmHg at 25°C
• Refractive Index: 1.562
• PKA: 4.01±0.10(Predicted)
• CAS DataBase Reference: 2-Methyl-2-(2-nitrophenyl)propanoicacid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-2-(2-nitrophenyl)propanoicacid(126802-52-6)
• EPA Substance Registry System: 2-Methyl-2-(2-nitrophenyl)propanoicacid(126802-52-6)

Safety Data

• Hazardous Substances Data: 126802-52-6(Hazardous Substances Data)

Usage

General Description

"2-Methyl-2-(2-nitrophenyl)propanoic acid" is a chemical compound with the molecular formula C11H13NO4. It is a derivative of the non-steroidal anti-inflammatory drug ibuprofen and is mainly used as a tool in the investigation of the pharmacology of prostaglandins. 2-Methyl-2-(2-nitrophenyl)propanoicacid has been studied for its potential therapeutic applications, including its anti-inflammatory and analgesic properties. Its structure consists of a nitrophenyl group attached to a methyl-substituted propanoic acid, giving it unique properties and potential medicinal uses.

InChI:InChI=1/C10H11NO4/c1-10(2,9(12)13)7-5-3-4-6-8(7)11(14)15/h3-6H,1-2H3,(H,12,13)

Upstream product

• 1195-98-8 2-methyl-2-phenylpropionitrile 
• 71825-51-9 4-(2-cyanoprop-2-yl)-1-nitrobenzene 
• 136764-87-9 2-methyl-2-(2-nitro-phenyl)-propionic acid methyl ester 

Downstream Products

• 154078-38-3 N-<4-(methylcarbonyl)phenyl>-2-methyl-2-(2-nitrophenyl)propanamide 
• 650629-18-8 5'-[2-methyl-2-(2-nitrophenyl)propionyl]-2'-deoxy-5-fluorouridine 
• 126802-51-5 potassium 2,2-dimethyl-2-(2-nitrophenyl)acetate 

Relevant articles and documents

5'-[2-(2-Nitrophenyl)-2-methylpropionyl]-2'-deoxy-5-fluorouridine as a potential bioreductively activated prodrug of FUDR: Synthesis, stability and reductive activation

5'-[2-(2-Nitrophenyl)-2-methylpropionyl]-2'-deoxy-5-fluorouridine was synthesized as a potential bioreductively activated prodrug of 5-fluoro-2'-deoxyuridine (FUDR). The target compound was stable in both phosphate buffer and human serum and was found to

Method for preparing and removing saccharide hydroxyl protecting group dimethyl phenylacetyl DMNA

The invention relates to a method for preparing and removing saccharide hydroxyl protecting group dimethyl phenylacetyl DMNA. The method comprises the following steps: (1) efficiently introducing saccharide hydroxyl protecting group dimethyl phenylacetyl into saccharide hydroxyl; and (2) efficiently removing a hydroxyl protecting group shown in the description. The method is environmentally friendly and has the advantages that the advantages that the preparation is simple, the introduction is efficient, the operation is easy, the removal is efficient, and the application range is wide; and furthermore, a protecting group has very good stereoselectivity when being used for protecting 2-hydroxyl of a glycosyl donor, so that the development and application of the protecting group are promoted.

Palladium-catalyzed decarboxylative coupling of potassium nitrophenyl acetates with aryl halides

A palladium-catalyzed decarboxylative cross-coupling of potassium 2- and 4-nitrophenyl acetates with aryl chlorides and bromides has been developed. Because the nitro group can be readily converted to many other functional groups, the new reaction provides a useful method for the preparation of diverse 1,1-diaryl methanes and their derivatives.