1268602-81-8Relevant articles and documents
Effects of steric hindrance and electron density of ester prodrugs on controlling the metabolic activation by human carboxylesterase
Takahashi, Masato,Hirota, Ibuki,Nakano, Tomoyuki,Kotani, Tomoyuki,Takani, Daisuke,Shiratori, Kana,Choi, Yura,Haba, Masami,Hosokawa, Masakiyo
, (2021)
Carboxylesterase (CES) plays an important role in the hydrolysis metabolism of ester–type drugs and prodrugs. In this study, we investigated the change in the hydrolysis rate of hCE1 by focusing on the steric hindrance of the ester structure and the elect