127-08-2

Basic information

• Product Name: Potassium Acetate
• Synonyms: Potassium acetate 99.98% trace metals basis, ~100 ppm Rb, ;Potassium acetate ACS reagent, >=99.0%;Potassium acetate anhydrous, free-flowing, Redi-Dri(TM), ACS reagent, >=99.0%;Potassium acetate puriss. p.a., >=99% (perchloric acid titration);Potassium acetate puriss., meets analytical specification of Ph. Eur., BP, E261, 99-101%;Potassium acetate ReagentPlus(R), >=99.0%;Potassium acetate Vetec(TM) reagent grade, 99%;EPA608-PERFORMANCE CHECK SOLUTION
• CAS NO: 127-08-2
• Molecular Formula: C₂H₃KO₂
• Molecular Weight: 98.14
• EINECS: 204-822-2
• Product Categories: AlphabeticalMolecular Biology;Biological Buffers;BioUltra Buffers;BioUltraBiological Buffers;Buffer SolutionsProtein Structural Analysis;Molecular Biology Reagents;Optimization Reagents;X-Ray Crystallography;Alphabetical Listings;Flavors and Fragrances;O-P;metal acetate salt;strongest trimerization catalyst;Food additives;Food additive;other chemicals;buffer, corrective, preservative, color protection
• Mol File: 127-08-2.mol
• Article Data: 24

Chemical Properties

• Melting Point: 292 °C
• Boiling Point: 117.1oC at 760 mmHg
• Flash Point: >250℃
• Appearance: White to light brown/Solid
• Density: 1.57 g/cm3 at 25 °C(lit.)
• Vapor Pressure: 13.9mmHg at 25°C
• Refractive Index: n20/D 1.370
• Storage Temp.: Store at RT.
• Solubility: H2O: 1 M at 20 °C, clear, colorless
• PKA: 4.756[at 20 ℃]
• Water Solubility: 2694 g/L (25 ºC)
• Sensitive: Hygroscopic
• Stability: Stability Deliquescent. Stable. Incompatible with strong oxidizing agents.
• Merck: 14,7605
• BRN: 3595449
• CAS DataBase Reference: Potassium Acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Potassium Acetate(127-08-2)
• EPA Substance Registry System: Potassium Acetate(127-08-2)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-25-23/24/25-21
• Safety Statements: 26-36-24/25-45-36/37/39
• WGK Germany: 1
• RTECS: AJ3325000
• TSCA: Yes
• Hazardous Substances Data: 127-08-2(Hazardous Substances Data)

Usage

Description

Different sources of media describe the Description of 127-08-2 differently. You can refer to the following data:
1. Potassium acetate is the potassium salt of acetic acid. It is manufactured through the reaction between a potassium base such as potassium hydroxide or potassium carbonate with acetic acid. It is an important macromineral with many physiological functions and is required for nerve conduction, cardiac, skeletal and smooth muscle contraction, energy generation, nucleic acid synthesis as well as mainlining the blood pressure and normal renal function. It can be taken as a nutritional supplement with antihypertensive effects and prevention effects against hypokalemia. It has several other common applications: (1) as a deicer; (2) as a food additive; (3) molecular biology applications such as DNA purification, tissue preservation, fixation and mummification; (4) Death penalty (5) as the catalyst during the production of polyurethanes.
2. Potassium acetate (CH3CO2K) is the potassium salt of acetic acid.

References

https://pubchem.ncbi.nlm.nih.gov/compound/Potassium_acetate#section=Top https://en.wikipedia.org/wiki/Potassium_acetate

Chemical Properties

Different sources of media describe the Chemical Properties of 127-08-2 differently. You can refer to the following data:
1. Potassium acetate, KC2H302, is a white, deliquescent solid, soluble in water and alcohol, insoluble in ether, that melts at 292°C. It is used as an analytical reagent, dehydrating agent, in medicine, and in crystal glass manufacture.
2. Pure potassium acetate is odorless or has a faint acetic odor and a saline taste.

Uses

Different sources of media describe the Uses of 127-08-2 differently. You can refer to the following data:
1. 1) Potassium acetate, crystalline powder, USP is, as its name suggests, the potassium salt of acetic acid and is used as a catalyst for producing polyurethanes2) In the food industry it is used as a food additive, an acidity regulator and a preservative
2. Used as buffers.
3. Potassium acetate is used in the manufacture of glass; as a softening agent for papers and textiles; as a dehydrating agent; and as a buffer. In medicine it is used as an expectorant and diuretic.
4. Potassium acetate was originally used in the preparation of Cadet's fuming liquid, the first organometallic compound produced. It is used as diuretic and urinary alkaliser, and acts by changing the physical properties of the body fluids and by functioning as an alkali after absortion.

Application

Potassium acetate is used as a catalyst in the production of polyurethanes.Potassium acetate can be used as a deicer instead of chloride salts such as calcium chloride or magnesium chloride. It offers the advantage of being less aggressive on soils and much less corrosive, and for this reason is preferred for airport runways. It is, however, more expensive. Potassium acetate is also the extinguishing agent used in class K fire extinguishers because of its ability to cool and form a crust over burning oils.3 – 1 - Food additive Potassium acetate is used as a food additive as a preservative and acidity regulator. In the European Union, it is labeled by the E number E261 ; it is also approved for usage in the USA and Australia and New Zealand. Potassium diacetate (CAS # 4251-29-0) with formula KH(O2CCH3)2 is a related food additive with the same E number as potassium acetate. 3 – 2 - Medicine and biochemistry In medicine, potassium acetate is used as part of replacement protocols in the treatment of diabetic ketoacidosis because of its ability to break down into bicarbonate and help neutralize the acidotic state. In molecular biology, potassium acetate is used to precipitate dodecyl sulfate (DS) and DS-bound proteins, allowing the removal of proteins from DNA. It is also used as a salt for the ethanol precipitation of DNA.

Preparation

Different sources of media describe the Preparation of 127-08-2 differently. You can refer to the following data:
1. Potassium Acetate can be prepared by treating a potassium-containing base such as potassium hydroxide or potassium carbonate with acetic acid: 2 CH3COOH + K2CO3→ 2 CH3CO2K + CO2 + H2O This sort of reaction is known as an acid-base neutralization reaction. Potassium acetate is the salt that forms along with water as acetic acid and potassium hydroxide are neutralized together. Conditions/substances to avoid are: moisture, heat, flames, ignition sources, and strong oxidizing agents.
2. Potassium acetate is prepared by addition of potassium carbonate in a small volume of water to acetic acid solution, followed by evaporation and crystallization: K2CO3+ 2CH3COOH →2CH3COOK + H2O

Definition

ChEBI: A potassium salt comprising equal numbers of potassium and acetate ions

General Description

Potassium acetate is generally used as an acidity regulator, buffer, preservative and firming agent.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C2H4O2.K/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1

Synthetic route

potassium 3-(bis[(N'-tert-butylureaylato)-N-ethyl]aminatomethyl)-5-tert-butyl-1H-pyrazolato(hydroxo)cobaltate(II) N,N-dimethylacetamide adduct (1/2) + ethyl acetate (141-78-6) → potassium acetate (127-08-2)

Conditions	Yield
In diethyl ether; N,N-dimethyl acetamide; ethyl acetate (Ar); vapor diffusion of Et2O into a (CH3)2NCOCH3/EtOAc soln. of Co complex;	100%
In N,N-dimethyl acetamide; ethyl acetate (Ar); stirred for 2 h at room temp.;

N,N-dimethyl acetamide (127-19-5) + bis[(N'-isopropylureido)-N-ethyl]-N-methylamine (1159806-92-4) + water (7732-18-5) + nickel diacetate (373-02-4, 14998-37-9, 33025-09-1, 94044-50-5, 98268-31-6) + potassium hydride → K[Ni(bis[(N'-isopropylureido)-N-ethyl]-N-methylamine(-2H))(hydroxo)]*DMA (1159806-63-9) + potassium acetate (127-08-2)

Conditions	Yield
In N,N-dimethyl acetamide (Ar); treatment of soln. of urea deriv. in dimethylacetamide with 2 equiv. of KH at room temp., addn. of 1 equiv. of nickel compd. at room temp., filtration, addn. of 1 equiv. of KH, addn. of 1 equiv. of water; evapn., triturating with ether, isolation of ppt., IR and UV;	A n/a B 99%
In N,N-dimethyl acetamide (Ar); treatment of soln. of urea deriv. in dimethylacetamide with 3 equiv. of KH at room temp., addn. of 1 equiv. of nickel compd. at room temp., stirring for 45 min, addn. of 1 equiv. of water, stirring for 20 min; filtration, diffusion of 1:1 ether/pentane vapour, isolation of crystals, elem. anal.;	A 64% B 98%

N,N-dimethyl acetamide (127-19-5) + 3-(bis[(N'-tert-butylureaylato)-N-ethyl]aminatomethyl)-5-tert-butyl-1H-pyrazole (1000006-56-3) + water (7732-18-5) + cobalt(II) acetate (71-48-7, 917-69-1, 5931-89-5, 55881-15-7, 68931-68-0, 68931-69-1, 93029-27-7) + potassium hydride → potassium 3-(bis[(N'-tert-butylureaylato)-N-ethyl]aminatomethyl)-5-tert-butyl-1H-pyrazolato(hydroxo)cobaltate(II) N,N-dimethylacetamide adduct (1/2) + potassium acetate (127-08-2)

Conditions	Yield
In N,N-dimethyl acetamide (Ar); a soln. of ligand treated with KH, Co salt added, stirred for 30 min, filtered, H2O added, stirred for 30 min; evapd. (vac., at room temp.), washed (Et2O), dried (vac.); elem. anal.;	A 83% B 98%

K[Ni(bis[(N'-isopropylureido)-N-ethyl]-N-methylamine(-2H))(hydroxo)]*DMA (1159806-63-9) + tetramethyl ammonium acetate (10581-12-1) + potassium hexamethylsilazane (40949-94-8) → [Ni(bis[(N'-isopropylureido)-N-ethyl]-N-methylamine(-2H))(oxo)](2-) + [tetramethylammonium]0.5K0.5[Ni(bis[(N'-isopropylureido)-N-ethyl]-N-methylamine(-2H))(OSiMe3)]*DMA + potassium acetate (127-08-2)

Conditions

Yield

In N,N-dimethyl acetamide (Ar); treatment of soln. of nickel compd. in dimethylacetamide with 1 equiv. of potassium amide deriv. at room temp., stirring for 30 min, addn.of tetramethylammonium salt at room temp., stirring for 1 h; filtration, evapn., triturating with diethyl ether, isolation of ppt., recrystn. by diffusion of 1:1 diethyl ether/pentane vapour into soln. in dimethylacetamide, elem. anal.;

A 0% B 94% C 98%

K[Ni(bis[(N'-tert-butylureido)-N-ethyl]-N-methylamine(-2H))(hydroxo)]*DMA (1159806-68-4) + potassium tert-butylate (865-47-4) + tetramethyl ammonium acetate (10581-12-1) → [Ni(bis[(N'-tert-butylureido)-N-ethyl]-N-methylamine(-2H))(oxo)](2-) + [tetramethylammonium][Ni(bis[(N'-tert-butylureido)-N-ethyl]-N-methylamine(-2H))(tert-butoxide)] (1159806-80-0) + potassium acetate (127-08-2)

Conditions	Yield
In N,N-dimethyl acetamide (Ar); treatment of soln. of nickel compd. in dimethylacetamide with 1 equiv. of potassium tert-butoxide at room temp., stirring for 30 min, addn. of tetramethylammonium salt at room temp., stirring for 1 h; filtration, evapn., triturating with diethyl ether, isolation of ppt., recrystn. by diffusion of diethyl ether vapour into soln. in dimethylacetamide, IR and UV;	A 0% B 78% C 96%

K[Ni(bis[(N'-tert-butylureido)-N-ethyl]-N-methylamine(-2H))(hydroxo)]*DMA (1159806-68-4) + tetramethyl ammonium acetate (10581-12-1) + potassium hexamethylsilazane (40949-94-8) → [Ni(bis[(N'-tert-butylureido)-N-ethyl]-N-methylamine(-2H))(oxo)](2-) + [tetramethylammonium][Ni(bis[(N'-tert-butylureido)-N-ethyl]-N-methylamine(-2H))(OSiMe3)] (1159806-88-8) + potassium acetate (127-08-2)

Conditions

Yield

In N,N-dimethyl acetamide (Ar); treatment of soln. of nickel compd. in dimethylacetamide with 1 equiv. of potassium amide deriv. at room temp., stirring for 30 min, addn.of tetramethylammonium salt at room temp., stirring for 1 h; filtration, evapn., triturating with diethyl ether, isolation of ppt., recrystn. by diffusion of 1:1 diethyl ether/pentane vapour into soln. in dimethylacetamide, IR and UV;

A 0% B 95% C n/a

bis[(N'-isopropylureido)-N-ethyl]-N-methylamine (1159806-92-4) + potassium tert-butylate (865-47-4) + tetramethyl ammonium acetate (10581-12-1) + nickel diacetate (373-02-4, 14998-37-9, 33025-09-1, 94044-50-5, 98268-31-6) → [tetramethylammonium][Ni(bis[(N'-isopropylureido)-N-ethyl]-N-methylamine(-2H))(tert-butoxide)] (1159806-75-3) + potassium acetate (127-08-2)

Conditions	Yield
With KH In N,N-dimethyl acetamide (vac. or Ar); treatment of soln. of urea deriv. in dimethylacetamide with KH, addn. of nickel compd., stirring for 45 min, addn. of potassium tert-butoxide, addn. of tetramethylammonium salt, stirring for 1 h; evapn. triturating with diethyl ether, isolation of ppt., elem. anal.;	A 91% B 89%

K[Ni(bis[(N'-isopropylureido)-N-ethyl]-N-methylamine(-2H))(hydroxo)]*DMA (1159806-63-9) + potassium tert-butylate (865-47-4) + tetramethyl ammonium acetate (10581-12-1) → [Ni(bis[(N'-isopropylureido)-N-ethyl]-N-methylamine(-2H))(oxo)](2-) + [tetramethylammonium][Ni(bis[(N'-isopropylureido)-N-ethyl]-N-methylamine(-2H))(tert-butoxide)] (1159806-75-3) + potassium acetate (127-08-2)

Conditions	Yield
In N,N-dimethyl acetamide (Ar); treatment of soln. of nickel compd. in dimethylacetamide with 1 equiv. of potassium tert-butoxide at room temp., stirring for 30 min, addn. of tetramethylammonium salt at room temp., stirring for 1 h; filtration, evapn., triturating with diethyl ether, isolation of ppt., recrystn. by diffusion of 1:1 ether/pentane vapour into soln. in dimethylacetamide, IR and UV;	A 0% B 91% C 89%

N,N-dimethyl acetamide (127-19-5) + water (7732-18-5) + nickel diacetate (373-02-4, 14998-37-9, 33025-09-1, 94044-50-5, 98268-31-6) + potassium hydride + bis[(N'-tert-butylureido)-N-ethyl]-N-methylamine (613221-93-5) → K[Ni(bis[(N'-tert-butylureido)-N-ethyl]-N-methylamine(-2H))(hydroxo)]*DMA (1159806-68-4) + potassium acetate (127-08-2)

Conditions	Yield
In N,N-dimethyl acetamide (Ar); treatment of soln. of urea deriv. in dimethylacetamide with 3 equiv. of KH at room temp., addn. of 1 equiv. of nickel compd. at room temp., stirring for 45 min, addn. of 1 equiv. of water, stirring for 20 min; filtration, diffusion of 1:1 ether/pentane vapour, isolation of crystals, elem. anal.;	A 87% B 84%

potassium hydroxide + acetylene (74-86-2) → potassium acetate (127-08-2)

Conditions	Yield
With water In melt byproducts: H2; 300°C, mixing, leading H2O vapor into the melt;	83%
With H2O In melt byproducts: H2; 300°C, mixing, leading H2O vapor into the melt;	83%
With air In water handling with air in presence of dild. aq. KOH in diffuse daylight at ambient temp.;
With air In water handling with air in presence of dild. aq. KOH in diffuse daylight at ambient temp.;

acetic acid tert-butyl ester (540-88-5) + potassium trimethylsilonate (10519-96-7) → potassium acetate (127-08-2)

Conditions	Yield
	77%

ethanol (64-17-5) → potassium acetate (127-08-2)

Conditions	Yield
With C15H27Br2CoN3; potassium hydroxide In toluene at 140℃; for 16h; Cannizzaro Reaction; Inert atmosphere; Sealed tube;	67%

O-acetyl-N-methoxyacetyl-hydroxylamine; potassium-compound → potassium acetate (127-08-2) + methoxymethyl isocyanate (6427-21-0)

Conditions	Yield
at 100℃;

acetic acid (64-19-7) → potassium acetate (127-08-2)

Conditions	Yield
With potassium carbonate
Stage #1: acetic acid With potassium hydroxide Electric arc; Stage #2: at 40 - 250℃;

4-acetoxy azetidinone (28562-53-0) → potassium acetate (127-08-2) + Potassium; (E)-2-carbamoyl-ethenolate

Conditions	Yield
With potassium hydroxide at 25℃; Mechanism; Rate constant;

vinyl crotonate (3234-54-6) + mercury(II) diacetate (1600-27-7) → (E)-but-2-enoic acid (107-93-7) + potassium acetate (127-08-2) + (formylmethyl)mercury chloride (5321-77-7)

Conditions	Yield
With potassium chloride 1.) water, 26 deg C; 2.) water; Yield given. Multistep reaction. Yields of byproduct given;

2-hydroxyethyl vinyl ether (764-48-7) → 2-methyl-1,3-dioxolane (497-26-7) + methane (34557-54-5) + ethane (74-84-0) + propane (74-98-6) + potassium acetate (127-08-2) + acetylene (74-86-2)

Conditions	Yield
With potassium hydroxide at 170℃; Product distribution; other hydroxides (Na, Li);

potassium 4-nitrophenolate (1124-31-8) + acetic anhydride (108-24-7) → potassium acetate (127-08-2) + 4-nitrophenol acetate (830-03-5)

Conditions	Yield
With 18-crown-6 ether In acetonitrile at 20℃; Rate constant; Equilibrium constant;
With 18-crown-6 ether In chlorobenzene at 25℃; Rate constant; Equilibrium constant;
In acetonitrile at 25℃; Kinetics; Equilibrium constant;

potassium 2,4-dinitrophenolate (14314-69-3) + acetic anhydride (108-24-7) → potassium acetate (127-08-2) + 2,4-dinitrophenyl acetate (4232-27-3)

Conditions	Yield
With 18-crown-6 ether In acetonitrile at 20℃; Rate constant; Equilibrium constant;
With 18-crown-6 ether In chlorobenzene at 25℃; Rate constant; Equilibrium constant;

acetic anhydride (108-24-7) + 4-hydroxybenzaldehyde potassium salt (58765-11-0) → 4-formylphenyl acetate (878-00-2) + potassium acetate (127-08-2)

Conditions	Yield
With 18-crown-6 ether In acetonitrile at 20℃; Rate constant;

acetic anhydride (108-24-7) + potassium salt of p-nitrosophenol (81409-00-9) → potassium acetate (127-08-2) + Acetic acid 4-nitroso-phenyl ester (83154-99-8)

Conditions	Yield
With 18-crown-6 ether In acetonitrile at 20℃; Rate constant;

di(4-acetoxybenzyl) methylphosphonate (136825-69-9) → (4-hydroxyphenyl)methanol (623-05-2) + potassium acetate (127-08-2) + potassium 4-acetoxybenzyl methylphosphonate

Conditions	Yield
In [D3]acetonitrile; water-d2 at 36.4℃; Mechanism; Rate constant; potassium phosphate buffer; half-live; also in the presence of porcine liver carboxyesterase;

potassium 4-nitrophenolate (1124-31-8) + acetic acid (64-19-7) → 4-nitro-phenol (100-02-7) + potassium acetate (127-08-2)

Conditions	Yield
In acetonitrile at 20℃; Equilibrium constant; Further equilibria;
In acetonitrile Equilibrium constant;

potassium salt of p-nitrosophenol (81409-00-9) + acetic acid (64-19-7) → p-nitrosophenol (104-91-6) + potassium acetate (127-08-2)

Conditions	Yield
In acetonitrile at 20℃; Equilibrium constant; Further equilibria;

di(4-acetoxybenzyl) methoxycarbonylmethylphosphonate (144758-70-3) → (4-hydroxyphenyl)methanol (623-05-2) + potassium acetate (127-08-2) + C12H14O7P(1-)*K(1+)

Conditions	Yield
In [D3]acetonitrile; water-d2 at 37℃; Mechanism; potassium phosphate buffer, porcine liver carboxyesterase; half-live; also with human plasma;

potassium 4-acetoxybenzyl methylphosphonate → (4-hydroxyphenyl)methanol (623-05-2) + potassium acetate (127-08-2) + dipotassium methylphosphonate (3999-19-7, 77354-28-0)

Conditions	Yield
In [D3]acetonitrile; water-d2 at 36.4℃; Mechanism; Rate constant; potassium phosphate buffer; half-live; also in the presence of porcine liver carboxyesterase;

lithium 4-acetoxybenzyl methoxycarbonylmethylphosphonate (144965-55-9) → (4-hydroxyphenyl)methanol (623-05-2) + potassium acetate (127-08-2) + C3H5O5P(2-)*2K(1+) (144965-64-0)

Conditions	Yield
In [D3]acetonitrile; water-d2 at 37℃; Mechanism; potassium phosphate buffer, porcine liver carboxyesterase; half-live; also with human plasma and with S9 fraction of porcine brain; also without any enzyme (velocity constant);

C8H6N3O8(1-)*K(1+) → 1,3,5-trinitrobenzene (99-35-4) + potassium acetate (127-08-2)

Conditions	Yield
With 18-crown-6 ether In acetonitrile at 15℃; Equilibrium constant; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔG(excit.);

acetic anhydride (108-24-7) + potassium salt of 2,3,5-trichlorophenol (58200-72-9) → potassium acetate (127-08-2) + 2,3,5-trichlorophenol acetate (61925-88-0)

Conditions	Yield
With 18-crown-6 ether In chlorobenzene at 25℃; Rate constant; Equilibrium constant;
In acetonitrile at 25℃; Kinetics; Equilibrium constant;

acetic anhydride (108-24-7) + 2-chloro-4-nitrophenol potassium salt → 2-chloro-4-nitrophenyl acetate (18855-84-0) + potassium acetate (127-08-2)

Conditions	Yield
With 18-crown-6 ether In chlorobenzene at 25℃; Rate constant; Equilibrium constant;
In acetonitrile at 25℃; Kinetics; Equilibrium constant;

potassium acetate (127-08-2) + benzyl chloride (100-44-7) → Benzyl acetate (140-11-4)

Conditions	Yield
Amberlyst A27 In toluene at 95℃; for 20h;	100%
With dicyclohexano-18-crown-6 In acetonitrile at 60℃; for 0.5h; Product distribution; further reagents;	85.4%
With zirconium (benzyldiethylammoniomethylphosphonate chloride) phosphate In water; toluene at 88℃; for 15h;	82.5%

potassium acetate (127-08-2) + 1-bromomethyl-4-nitro-benzene (100-11-8) → 4-nitrobenzyl acetate (619-90-9)

Conditions	Yield
5,11,17,23,29,35-Hexa-p-tert-butyl-37,38,39,40,41,42-hexakis-(3,6,9-trioxadecyloxy)calix<6>arene In dichloromethane at 40℃; for 24h;	100%
5,11,17,23,29,35-Hexa-p-tert-butyl-37,38,39,40,41,42-hexakis-(3,6,9-trioxadecyloxy)calix<6>arene In dichloromethane; water at 40℃; for 24h;	100%
"octopus-type" calixarene 1 In dichloromethane; water at 40℃; for 24h; Product distribution; other catalysts, content of water, other carboxylates;	100%
With ethanol
5,11,17,23,29,35-hexa-....-calix<6>arene In dichloromethane at 40℃; for 24h; influence of other catalysts;

naphth-1-yl acetic acid (86-87-3) + potassium acetate (127-08-2) → naphthalen-1-ylmethyl acetate (13098-88-9)

Conditions	Yield
With dipotassium peroxodisulfate; copper diacetate In acetic acid for 2h; Heating;	100%

1-bromo-octane (111-83-1) + potassium acetate (127-08-2) → n-octyl acetate (112-14-1)

Conditions	Yield
Sucrose-ethyleneoxide adducts In acetonitrile at 83℃; for 24h; Product distribution; further catalysts: PEG, DB18K6; further objects of study: phase-transfer catalysis; further solvents: toluene/H2O;	100%
With aluminum oxide at 196℃; for 0.0333333h; Irradiation; other long chain halides;	99%
With aluminum oxide at 196℃; for 0.0333333h; Irradiation;	99%

(S)-2,2'-bis(bromomethyl)-1,1'-binaphthyl (37803-02-4) + potassium acetate (127-08-2) → (S)-2,2'-Bis-1,1'-binaphthyl (98834-92-5)

Conditions	Yield
With tetrabutylammomium bromide In N,N-dimethyl-formamide at 80℃; for 20h;	100%
With tetrabutylammomium bromide In N,N-dimethyl-formamide at 80℃;

potassium acetate (127-08-2) + methyl <1S-<1α,2α(Z),3α,4α>>-7-<3-<(tosyloxy)methyl>-7-oxabicyclo<2.2.1>hept-2-yl>-5-heptanoate (107437-25-2) → Methyl <1S-<1α,2α(Z),3α,4α>>-7-<3-<<(2-Oxo-2-ethyl)thio>methyl>-7-oxabicyclo<2.2.1>hept-2-yl>-5-heptenoate (119785-38-5)

Conditions	Yield
In tetrahydrofuran; dimethyl sulfoxide at 75℃; for 1.25h;	100%

potassium acetate (127-08-2) + endo-5,6-dimethylidene-2-norbornyl brosylate → (3-methylidene-2-nortricyclyl)methyl acetate + 5,6-dimethylidene-2exo-norbornyl alcohol acetate

Conditions	Yield
With acetic anhydride for 96h; Yields of byproduct given;	A 100% B n/a
With acetic anhydride In acetic acid at 25℃; for 72h; Yield given. Yields of byproduct given;

potassium acetate (127-08-2) + C9H16ClN2O2 → 2,2,6,6-tetramethyl-3-acetoxy-4-oximinopiperidin-1-oxyl

Conditions	Yield
In acetone for 1h;	100%

potassium acetate (127-08-2) + benzyl bromide (100-39-0) → Benzyl acetate (140-11-4)

Conditions	Yield
Sucrose-ethyleneoxide adducts In acetonitrile at 20℃; for 8h; Product distribution; further catalysts: PEG, DB18K6; further objects of study: phase-transfer catalysis; further solvents: toluene/H2O;	100%
With ammonium salt In neat (no solvent) for 2h; Ambient temperature;	99%
With tetradecane; potassium acetate; magnetic nanoparticle-supported crown ether In toluene at 80℃; for 8h;	96%

1,4-bis(decyloxy)benzene (129236-97-1) + potassium acetate (127-08-2) → Acetic acid 4-acetoxymethyl-2,5-bis-decyloxy-benzyl ester (444308-62-7)

Conditions	Yield
With tetrabutylammomium bromide In chloroform; acetonitrile Heating;	100%

potassium acetate (127-08-2) → 3-bromo-7-hydroxymethyl-9-fluorenone (136682-02-5)

Conditions	Yield
With sodium methylate In tetrahydrofuran; methanol for 1.25h; Ambient temperature;	100%

potassium acetate (127-08-2) + D-3-O-trifluoromethanesulfonyl-1,2:4,5-di-O-isopropylidene-myo-inositol (685539-84-8) → 1L-1-O-acetyl-2,3:5,6-di-O-isopropylidene-chiro-inositol (685539-85-9)

Conditions	Yield
In N,N-dimethyl acetamide at 70℃;	100%

potassium acetate (127-08-2) + D-3,6-di-O-trifluoromethanesulfonyl-1,2:4,5-di-O-isopropylidene-myo-inositol (685539-87-1) → (D)-2,5-di-O-acetyl-1,6:3,4-di-O-isopropylidene-allo-inositol (685539-88-2)

Conditions	Yield
In N,N-dimethyl acetamide at 70℃;	100%

potassium acetate (127-08-2) + (3Z)-3-(chloromethyl)-4-(4-chlorophenyl)but-3-en-2-one (232944-74-0) → Acetic acid 2-[1-(4-chloro-phenyl)-meth-(E)-ylidene]-3-oxo-butyl ester

Conditions	Yield
With 1-n-butyl-methylimidazolium tetrafluoroborate at 45 - 50℃; for 2h;	100%

potassium acetate (127-08-2) + (Z)-3-Chloromethyl-4-(4-fluoro-phenyl)-but-3-en-2-one → Acetic acid 2-[1-(4-fluoro-phenyl)-meth-(E)-ylidene]-3-oxo-butyl ester

Conditions	Yield
With 1-n-butyl-methylimidazolium tetrafluoroborate at 45 - 50℃; for 2h;	100%

potassium acetate (127-08-2) + (+/-)-1,2:4,5-di-O-isopropylidene-3-O-trifluorometnanesulfonyl-myo-inositol → rac-1-O-acetyl-2,3:5,6-di-O-isopropylidene-chiro-inositol

Conditions	Yield
In N,N-dimethyl acetamide at 70℃;	100%

4-(tert-butyl)-2,6-bis(phenylazo)benzyl bromide + potassium acetate (127-08-2) → 4-(tert-butyl)-2,6-bis(phenylazo)benzyl acetate

Conditions	Yield
In acetone; acetonitrile for 0.75h;	100%

3-bromo-2-(bromomethyl)-1-nitrobenzene (58579-54-7) + potassium acetate (127-08-2) → 2-bromo-6-nitrobenzyl acetate (861106-90-3)

Conditions	Yield
In DMF (N,N-dimethyl-formamide) at 70℃; for 1h;	100%
In N,N-dimethyl-formamide at 70℃; for 1h;
In N,N-dimethyl-formamide at 80℃; for 4h;	14.5 g

1-(5-(bromomethyl)-1-methyl-1H-pyrazol-4-yl)ethanone (1027329-29-8) + potassium acetate (127-08-2) → (4-acetyl-1-methyl-1H-pyrazol-5-yl)methyl acetate (1027329-30-1)

Conditions	Yield
18-crown-6 ether In acetonitrile at 20℃; for 20h;	100%

5-bromo-7-(bromomethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole (1100212-54-1) + potassium acetate (127-08-2) → (5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-7-yl)methyl acetate (1100213-62-4)

Conditions	Yield
In N,N-dimethyl-formamide at 20 - 40℃; for 1.16667h;	100%

tetrabutyl-ammonium chloride (1112-67-0) + potassium acetate (127-08-2) → tetrabutylammonium acetate (10534-59-5)

Conditions	Yield
In methanol	100%
In methanol for 24h; Inert atmosphere;
In methanol for 24h; Inert atmosphere;

2-(1-chloroethyl)-5-(3-chlorophenyl)-1,3,4-oxadiazole (660417-35-6) + potassium acetate (127-08-2) → 1-[5-(3-chlorophenyl)-1,3,4-oxadiazol-2-yl]ethyl acetate (1196958-32-3)

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 24h;	100%

18-crown-6 ether (17455-13-9) + potassium acetate (127-08-2) → C2H3O2(1-)*C12H24KO6

Conditions	Yield
In water at 20℃; for 12h;	100%

potassium acetate (127-08-2) + 2-bromo-4-chloro-1-phenylbutan-1-one (52868-15-2) → C12H13ClO3

Conditions	Yield
In acetonitrile	100%

C12H11Br2FO2 (1359856-96-4) + potassium acetate (127-08-2) → C14H14BrFO4 (1359856-97-5)

Conditions	Yield
In N,N-dimethyl-formamide at 50℃; for 1h;	100%

potassium acetate (127-08-2) + 1,4-bis(bromomethyl)-2,5-bis-(dodecyloxy)benzene (122996-59-2) → 2,5-bis(acetyl methyl)-1,4-bis(dodecyloxy)benzene (237757-95-8)

Conditions	Yield
With N-butylammonium bromide In chloroform; acetonitrile for 2h; Reflux;	100%
With tetrabutylammomium bromide In chloroform; acetonitrile for 12h; Reflux;	88%

potassium acetate (127-08-2) + 2-bromo-4-chloro-1-phenylbutan-1-one (52868-15-2) → C12H13ClO2

Conditions	Yield
In acetonitrile Reflux;	100%

3-(bromomethyl)-1-(3-chloro-5-fluoro-phenoxy)-2-(difluoromethyl)-4-methylsulfonylbenzene + potassium acetate (127-08-2) → [3-(3-chloro-5-fluoro-phenoxy)-2-(difluoromethyl)-6-methylsulfonyl-phenyl]methyl acetate

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 0.333333h;	100%

tert-butyl 4-(7-bromo-6-chloro-2-(chloromethyl)-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate + potassium acetate (127-08-2) → tert-butyl 4-(2-(acetoxymethyl)-7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate

Conditions	Yield
In dimethyl sulfoxide at 80℃; for 2h;	100%

Upstream product

• 64-19-7 acetic acid 
• 28562-53-0 4-acetoxy azetidinone 
• 1006-65-1 3-phenylisoxazole 
• 75-65-0 tert-butyl alcohol 
• 5912-58-3 1-chloroethyl acetate 
• 57752-15-5 3-[bis-(4-dimethylamino-phenyl)-methyl]-pentane-2,4-dione 
• 122-46-3 3-acetoxytoluene 
• 830-03-5 4-nitrophenol acetate 
• 7789-23-3 potassium fluoride 
• 7782-77-6 cis-nitrous acid 
• 540-59-0 1,2-Dichloroethylene 
• 56-81-5 glycerol 
• 64-17-5 ethanol 
• 7440-09-7 potassium 

Downstream Products

• 74580-97-5 O⁵-acetyl-O¹,O²-isopropylidene-O³-(toluene-4-sulfonyl)-α-L-xylofuranose 
• 3341-53-5 (2S)-2r-ethoxy-3c-(3,4-dimethoxy-phenyl)-5,7-dimethoxy-chroman 
• 116935-88-7 acetate of (+)-catechin 
• 1679-47-6 3-methyltetrahydro-2-furanone 
• 51238-15-4 4β-acetoxycholest-5-en-3β-ol 
• 5470-86-0 1,2,5-triacetoxypentane 
• 332-77-4 2,5-dihydro-2,5-dimethoxyfuran 
• 859303-52-9 2-Acetoxy-5-methoxy-2,5-dihydro-furan 
• 7501-29-3 4,6-dioxopyrimido-2,1,3-thiadiazole 
• 5682-79-1 3,5-dibromo-2,6-dimethylhepta-2,5-dien-4-one 
• 4753-59-7 4-Bromobutyl acetate 
• 628-67-1 butane-1,4-diol diacetate 
• 875249-59-5 1-(2,2-dimethyl-3-nitro-cyclopropyl)-ethanone 
• 10312-37-5 methyl 4-nitropentanoate 

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