1270284-15-5

Basic information

• Product Name: (S)-5-bromo-2,3-dihydro-1H-inden-1-ol
• Synonyms: (S)-5-bromo-2,3-dihydro-1H-inden-1-ol;1H-Inden-1-ol, 5-bromo-2,3-dihydro-, (1S)-
• CAS NO: 1270284-15-5
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213.07116
• Mol File: 1270284-15-5.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-5-bromo-2,3-dihydro-1H-inden-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-5-bromo-2,3-dihydro-1H-inden-1-ol(1270284-15-5)
• EPA Substance Registry System: (S)-5-bromo-2,3-dihydro-1H-inden-1-ol(1270284-15-5)

Safety Data

• Hazardous Substances Data: 1270284-15-5(Hazardous Substances Data)

Usage

Description

(S)-5-bromo-2,3-dihydro-1H-inden-1-ol is a chiral chemical compound with the molecular formula C9H9BrO. It is a colorless to pale yellow liquid at room temperature and possesses a specific stereochemistry. (S)-5-bromo-2,3-dihydro-1H-inden-1-ol is known for its unique structure and reactivity, making it a versatile building block for producing various biologically active molecules.

Uses

Used in Pharmaceutical Industry:
(S)-5-bromo-2,3-dihydro-1H-inden-1-ol is used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. Its unique structure and reactivity make it a valuable component in the development of new drugs and materials.
Used in Asymmetric Catalysis:
(S)-5-bromo-2,3-dihydro-1H-inden-1-ol is used as a chiral ligand in chemical reactions, particularly in asymmetric catalysis. Its specific stereochemistry allows for the selective formation of desired enantiomers, which is crucial in the production of enantioselective pharmaceuticals and other chiral compounds.
Used in Organic Synthesis:
(S)-5-bromo-2,3-dihydro-1H-inden-1-ol is used as a versatile building block in organic synthesis. Its unique structure and reactivity enable the production of various biologically active molecules, contributing to the development of new drugs and materials.

Upstream product

• 34598-50-0 5-bromo-1-indanol 
• 34598-49-7 5-Bromo-1-indanone 

Downstream Products

• 1334782-79-4 (R)-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-1-(2-(5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonan-7-yl)ethanone 
• 1228561-27-0 (1R)-5-bromo-2,3-dihydro-1H-inden-1-amine 
• 1334785-10-2 tert-butyl 2-[(R)-5-(4-carbamoylphenyl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate 
• 1334785-11-3 4-[(R)-1-(2,7-diaza-spiro[3.5]non-2-yl)-indan-5-yl]-benzamide hydrochloride 
• 1334782-54-5 2-(4-methoxyphenyl)-1-{2-[(1R)-5-(pyrimidin-2-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}ethanone 
• 1334783-29-7 4-[(1R)-1-{7-[(7-methylimidazo[1,2-a]pyridin-2-yl)acetyl]-2,7-diazaspiro[3.5]non-2-yl}-2,3-dihydro-1H-inden-5-yl]benzamide 
• 1334785-21-5 5-methyl-2-{2-oxo-2-[2-((R)-5-pyrimidin-2-yl-indan-1-yl)-2,7-diaza-spiro[3.5]non-7-yl]ethyl}benzoic acid 
• 1334783-53-7 5-methyl-2-(2-oxo-2-{2-[(1R)-5-pyrimidin-2-yl-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl}ethyl)benzamide 
• 1346229-01-3 (S)-benzyl 5-bromo-2,3-dihydro-1H-inden-1-ylcarbamate 
• 1346228-93-0 (S)-1-(benzyloxy)-5-bromo-2,3-dihydro-1H-indene 
• 903555-98-6 tert-butyl N-[(1R)-5-bromo-2,3-dihydro-1H-inden-1-yl]carbamate 

Relevant articles and documents

Kinetic resolution of racemic benzofused alcohols catalysed by HMFO variants in presence of natural deep eutectic solvents

5-Hydroxymethylfurfural oxidase (HMFO) has demonstrated to be a useful biocatalyst for the selective oxidation of alcohols employing oxygen as mild oxidant with no requirement of expensive organic cofactors. This wild-type HMFO biocatalyst and an engineered thermostable variant have been tested in the kinetic resolution of different benzofused alcohols. The use of natural deep eutectic solvents was also explored in HMFO-catalysed oxidation of alcohols. The oxidation of racemic 1-indanol showed a higher conversion and selectivity in presence of 60% v/v of different NADES, especially for those containing carbohydrates. By choosing properly the biocatalyst and the NADES, good enantioselectivity values can be obtained, demonstrating the advantages of employing these neoteric solvents in biocatalysed processes.

DIHYDROBENZOFURAN AND INDEN ANALOGS AS CARDIAC SARCOMERE INHIBITORS

Provided are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein A, Z, B, R1, R2, R3, G1, G2, and G3 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt, thereof for use in methods of treatment heart diseases through cardiac sarcomere inhibtion.

Ansa-Ruthenium(II) Complexes of R2NSO2DPEN-(CH2)n(η6-Aryl) Conjugate Ligands for Asymmetric Transfer Hydrogenation of Aryl Ketones

New 3rd generation designer ansa-ruthenium(II) complexes featuring N,C-alkylene-tethered N,N-dialkylsulfamoyl-DPEN/η6-arene ligands, exhibited good catalytic performance in the asymmetric transfer hydrogenation (ATH) of various classes of (het)aryl ketones in formic acid/triethylamine mixture. In particular, benzo-fused cyclic ketones furnished 98 to >99.9% ee using a low catalyst loading.