1273277-80-7Relevant articles and documents
Designer nanorings with functional cavities from self-assembling β-Sheet peptides
Park, Il-Soo,Yoon, You-Rim,Jung, Minseon,Kim, Kimoon,Park, Seongbyeong,Shin, Seokmin,Lim, Yong-Beom,Lee, Myongsoo
supporting information; experimental part, p. 452 - 458 (2011/10/03)
β-Barrel proteins that take the shape of a ring are common in many types of water-soluble enzymes and water-insoluble transmembrane pore-forming proteins. Since β-barrel proteins perform diverse functions in the cell, it would be a great step towards developing artificial proteins if we can control the polarity of artificial β-barrel proteins at will. Here, we describe a rational approach to construct β-barrel protein mimics from the self-assembly of peptide-based building blocks. With this approach, the direction of the self-assembly process toward the formation of water-soluble β-barrel nanorings or water-insoluble transmembrane β-barrel pores could be controlled by the simple but versatile molecular manipulation of supramolecular building blocks. This study not only delineates the basic driving force that underlies the folding of β-barrel proteins, but also lays the foundation for the facile fabrication of β-barrel protein mimics, which can be developed as nanoreactors, ion- and small-molecule-selective pores, and novel antibiotics. Copyright