1274926-89-4

Basic information

• Product Name: 6,6'-bis(2-hydroxy-2-methylpropyl)-1,1'-binaphthyl-2,2'-diol
• Synonyms: 6,6'-bis(2-hydroxy-2-methylpropyl)-1,1'-binaphthyl-2,2'-diol
• CAS NO: 1274926-89-4
• Molecular Weight: 430.544
• Mol File: 1274926-89-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6,6'-bis(2-hydroxy-2-methylpropyl)-1,1'-binaphthyl-2,2'-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 6,6'-bis(2-hydroxy-2-methylpropyl)-1,1'-binaphthyl-2,2'-diol(1274926-89-4)
• EPA Substance Registry System: 6,6'-bis(2-hydroxy-2-methylpropyl)-1,1'-binaphthyl-2,2'-diol(1274926-89-4)

Safety Data

• Hazardous Substances Data: 1274926-89-4(Hazardous Substances Data)

Upstream product

• 558-30-5 2-methyl-1,2-epoxypropane 
• 79082-80-7 (S)-6,6'-dibromo-1,1'-binaphthalene-2,2'-diol 

Relevant articles and documents

Protecting group free synthesis of 6-substituted naphthols and binols

A straightforward route for the preparation of 6-substituted naphthols and 6,6′-disubstituted binols (binol = 2,2′-dihydroxy-1,1′- binaphthyl) is presented. The synthesis has been accomplished by a one-step procedure starting from 6-bromo derivatives via direct lithiation with n-BuLi, followed by the addition of several electrophiles. This C-C functionalization has been successfully achieved with iodomethane, 3-methoxybenzaldehyde, benzophenone, methyl-2-methylbenzoate, methylbenzoate, dimethyl carbonate, ethyl 2-chloro-2-oxoacetate, and 2,2-dimethyloxirane (E). This reactivity offers a useful protecting group free synthetic protocol, toward chiral disubstituted 6,6′-binols with configuration retention of the binol moiety.