127555-83-3

Basic information

• Product Name: 1-(2,4-Difluoro-phenyl)-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one
• CAS NO: 127555-83-3
• Molecular Weight: 246.216
• Mol File: 127555-83-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2,4-Difluoro-phenyl)-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-Difluoro-phenyl)-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one(127555-83-3)
• EPA Substance Registry System: 1-(2,4-Difluoro-phenyl)-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one(127555-83-3)

Safety Data

• Hazardous Substances Data: 127555-83-3(Hazardous Substances Data)

Upstream product

• 101012-32-2 2-(2-chloropyridin-3-yl)acetonitrile 
• 6635-88-7 3-(cyanomethyl)pyridine 1-oxide 
• 6443-85-2 3-pyridinylacetonitrile 
• 61494-55-1 2-Chloro-pyridin-3-yl acetic acid 
• 367-25-9 2,4-difluorophenylamine 

Downstream Products

• 127555-37-7 1-(2,4-difluorophenyl)-1,3-dihydro-3,3-dimethyl-2H-pyrrolo[2,3-b]pyridin-2-one 

Relevant articles and documents

Substituted 1,3-Dihydro-2H-pyrrolopyridin-2-ones as Potential Antiinflammatory Agents

A series of analogues based on the 1,3-dihydro-2H-pyrrolopyridin-2-one ring system have been synthesized and shown to possess oral antiinflammatory activity in both the reverse passive Arthus reaction (RPAR) pleural cavity assay in rats and in the adjuvant-induced arthritic rat model (AAR).Several members of this series additionally exhibit an inhibitory effect on the in vivo production of prostaglandin- and leukotriene-derived products or arachidonic acid metabolism although these compounds exhibit no significant inhibitory activity against the cyclooxygenase and 5-lipoxygenase enzymes in vitro.Structure-activity relationships in this series are discussed.