127680-87-9 Usage
General Description
2-Pyrrolidin-1-ylisonicotinonitrile, also known as ML285, is a chemical compound with potential therapeutic applications. It belongs to the class of pyrrolidine-containing compounds and is utilized in pharmaceutical research as a potent and selective agonist of the alpha-7 nicotinic acetylcholine receptor. This receptor plays a crucial role in the central nervous system and is implicated in various cognitive and neurological disorders. ML285 has been studied for its potential in treating conditions such as Alzheimer's disease, schizophrenia, and cognitive deficits. Additionally, it has shown promise in preclinical studies for its ability to enhance memory and cognitive function. As a result, ML285 is being investigated as a potential drug candidate for the treatment of neurological and cognitive disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 127680-87-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,6,8 and 0 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 127680-87:
(8*1)+(7*2)+(6*7)+(5*6)+(4*8)+(3*0)+(2*8)+(1*7)=149
149 % 10 = 9
So 127680-87-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H11N3/c11-8-9-3-4-12-10(7-9)13-5-1-2-6-13/h3-4,7H,1-2,5-6H2
127680-87-9Relevant articles and documents
A Study of the Photochemically Induced Electron-Transfer Reactions Between Pyridinedicarbonitriles and Primary and Secondary Aliphatic Amines
Bernardi, Rosanna,Caronna, Tullio,Poggi, Gabriella,Vittimberga, Bruno M.
, p. 903 - 908 (2007/10/02)
A study on the photochemically induced electron-transfer from primary and secondary aliphatic amines as donors to pyridinecarbonitriles as the acceptor is reported.A comparison between the substitution positions and the spin density distributions, obtained via teoretical calculations using the 6-31+G basis set, shows some discrepancies, and forms the basis of a hypothesis on the mechanism of the reaction.
