127753-24-6Relevant articles and documents
Synthesis and microbiological activity of 5-methyl-2-benzoxazoles
Yalcin, I.,Sener, E.,Oezden, T.,Oezden, S.,Akin, A.
, p. 705 - 708 (1990)
The synthesis and microbiological activity of a series of 5-methyl-2-(p-substituted phenyl)benzoxazoles 7a-7g are described.The in vitro microbiological activity of these compounds was determined against some Gram-positive and Gram-negative bacteria and C albicans.The observed minimum inhibitory concentration (MIC) values of the derivatives were compared to some other 2,5-disubstituted benzoxazoles and clinically used drugs.The in vitro microbiological data showed that the derivatives 7a-7g exhibited a broad spectrum of antibacterial activity and 7a-c and 7g were significantly active against E coli and/or K pneumoniae at an MIC of 6.2 μg/ml.