12777-70-7

Basic information

• Product Name: dryocrassin
• Synonyms: dryocrassin;Dryocrassin ABBA);Methylenebisnorflavaspidic acid ABBA;Tetraalbaspidin ABBA
• CAS NO: 12777-70-7
• Molecular Formula: C₄₃H₄₈O₁₆
• Molecular Weight: 820.83162
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 12777-70-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 1011.9°Cat760mmHg
• Flash Point: 579.5°C
• Appearance: /
• Density: 1.474±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.673
• PKA: 4.20±1.00(Predicted)
• CAS DataBase Reference: dryocrassin(CAS DataBase Reference)
• NIST Chemistry Reference: dryocrassin(12777-70-7)
• EPA Substance Registry System: dryocrassin(12777-70-7)

Safety Data

• Hazardous Substances Data: 12777-70-7(Hazardous Substances Data)

Usage

Biological Activity

Dryocrassin is a flavonoid natural product, a phloroglucinol derivative derived from Dryopteris crassirhizoma, with antiviral and antibacterial activities. Biological and pharmacological activities of dryocrassin have attracted attention. Dryocrassin exhibits antiviral activity against H5N1 avian influenza virus. Dryocrassin inhibits the coagulase activity of Staphylococcus aureus vWbp. Dryocrassin suppresses immunostimulatory function of dendritic cells and prolongs skin allograft survival.

InChI:InChI=1/C43H48O16/c1-9-11-24(46)28-32(50)18(30(48)20(34(28)52)14-22-36(54)26(16(3)44)40(58)42(5,6)38(22)56)13-19-31(49)21(35(53)29(33(19)51)25(47)12-10-2)15-23-37(55)27(17(4)45)41(59)43(7,8)39(23)57/h48-57H,9-15H2,1-8H3

Upstream product

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Related news

Total synthesis of dryocrassin (cas 12777-70-7) ABBA and its analogues with potential inhibitory activity against drug-resistant neuraminidases08/27/2019

The stems of Dryopteris crassirhizoma, one of the main components of Lianhua-Qingwen Formula (LQF) was traditionally used for heat-clearing and detoxifying. Dryocrassin ABBA is a key antiviral component in the herbal medicine while the compound is hard to get in large amounts with the features o...detailed

Relevant articles and documents

Total synthesis of dryocrassin ABBA and its analogues with potential inhibitory activity against drug-resistant neuraminidases

The stems of Dryopteris crassirhizoma, one of the main components of Lianhua-Qingwen Formula (LQF) was traditionally used for heat-clearing and detoxifying. Dryocrassin ABBA is a key antiviral component in the herbal medicine while the compound is hard to