127785-96-0 Usage
General Description
6-Aminomethyl-6,11-dihydro-5H-dibenz[b,e]azepine (E)-2-butenedioate is a chemical compound that is also known as clozapine. It is an antipsychotic medication that is used to treat schizophrenia, as well as reducing the risk of suicidal behavior in people with schizophrenia or similar disorders. Clozapine works by affecting the balance of chemicals in the brain, specifically by blocking the receptors for dopamine and serotonin. It is typically taken orally and has been shown to be effective in treating the symptoms of schizophrenia, such as hallucinations, delusions, and disorganized thinking. However, it is associated with potentially serious side effects, including a risk of agranulocytosis, which is a severe decrease in white blood cells, as well as seizures, myocarditis, and other adverse reactions. Therefore, it is generally reserved for patients who have not responded to other antipsychotic medications.
Check Digit Verification of cas no
The CAS Registry Mumber 127785-96-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,7,8 and 5 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 127785-96:
(8*1)+(7*2)+(6*7)+(5*7)+(4*8)+(3*5)+(2*9)+(1*6)=170
170 % 10 = 0
So 127785-96-0 is a valid CAS Registry Number.
InChI:InChI=1/C15H16N2.C4H4O4/c16-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)17-15;5-3(6)1-2-4(7)8/h1-8,15,17H,9-10,16H2;1-2H,(H,5,6)(H,7,8)/b;2-1+
127785-96-0Relevant articles and documents
A new process for the preparation of 3-amino-9,13b-dihydro-1H-dibenz [c,f] imidazo[1,5-a]azepine bromic acid salt
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, (2016/12/07)
The present invention relates to a novel method for preparing an enhanced 3-amino-9, 13b-dihydro-1H-dibenz [c,f] imidazo [1,5-a] azepine bromic acid salt. The compound is used as an intermediate in manufacturing the epinastine hydrochloride. The compound is represented by the structural formula (I).COPYRIGHT KIPO 2015
METHOD FOR PREPARING 6-AMINOMETHYL-6,11-DIHYDRO-5H-DIBENZ(B,E)AZEPINE
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Page 3, (2010/02/10)
A production method of 6-aminomethyl-6,11-dihydro-5H-dibenz[b,e]azepin characterized in that said compound is produced via N-[(6,11-dihydro-5H-dibenz[b,e]azepin-6-yl)methyl]-o-hydroxymethylbenzamide which is prepared by reducing 2-(11H-dibenz[b,e]azepin-6-ylmethyl)-1H-isoindole-1,3(2H)-dione employing a metal hydride or a metal hydride complex in a water based alcohol, and N-[(6,11-dihydro-5H-dibenz[b,e]azepin-6-yl)methyl]-o-hydroxymethylbenzamide which is useful for the aforesaid production method.