127786-29-2

Basic information

• Product Name: Epinastine hydrobromide
• Synonyms: (+/-)-3-amino-9,13b-dihydro-1h-dibenz[c,f]imidazo[1,5-a]azepine hydrobromide;epinastine hydrobromide;EPINASTIN HBR;Epinastine HBr;9,13b-Dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine hydrobromide
• CAS NO: 127786-29-2
• Molecular Formula: BrH*C₁₆H₁₅N₃
• Molecular Weight: 330.22234
• EINECS: 1312995-182-4
• Mol File: 127786-29-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 284-286°
• Boiling Point: 428 °C at 760 mmHg
• Flash Point: 212.7 °C
• Appearance: /
• Vapor Pressure: 1.56E-07mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Epinastine hydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: Epinastine hydrobromide(127786-29-2)
• EPA Substance Registry System: Epinastine hydrobromide(127786-29-2)

Safety Data

• Hazardous Substances Data: 127786-29-2(Hazardous Substances Data)

Usage

General Description

Epinastine hydrobromide is a second-generation H1 receptor antagonist that is used as an antihistamine for the treatment of allergic conjunctivitis (itchy, watery eyes) and other allergic reactions. It works by blocking the action of histamine, a chemical released by the body during an allergic reaction, and helps to relieve symptoms such as itching and redness. Epinastine hydrobromide is available in ophthalmic solution form and is used to provide rapid and lasting relief for those suffering from allergic eye conditions. It is considered to be a safe and effective treatment option for individuals with allergic conjunctivitis.

InChI:InChI=1/C16H15N3.BrH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H

Upstream product

• 21535-44-4 6-(chloromethyl)-11H-dibenzazepine 
• 21535-43-3 N-[2-(phenylmethyl)phenyl]-2-chloroacetamide 
• 41218-84-2 6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azepine 
• 80012-69-7 11H-dibenzazepine-6-carbonitrile 
• 4998-12-3 6-chloro-11H-dibenzazepine 
• 506-68-3 bromocyane 

Downstream Products

• 80012-43-7 epinastine 
• 108929-04-0 epinastine hydrochloride 

Relevant articles and documents

A new process for the preparation of 3-amino-9,13b-dihydro-1H-dibenz [c,f] imidazo[1,5-a]azepine bromic acid salt

The present invention relates to a novel method for preparing an enhanced 3-amino-9, 13b-dihydro-1H-dibenz [c,f] imidazo [1,5-a] azepine bromic acid salt. The compound is used as an intermediate in manufacturing the epinastine hydrochloride. The compound is represented by the structural formula (I).COPYRIGHT KIPO 2015

New tetracyclic guanidine derivatives with H1-antihistaminic properties. Chemistry of epinastine

A series of new tetracyclic guanides were synthesized by various methods. Specific binding of the described compounds to histamine-1 and histamine-2 receptors was determined. The compound 3-amino-9, 13b-dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepine (epinastine, WAL 801) combines high selectivity with high affinity for the H1 receptor and was selected from the compounds studied for further pharmacological and clinical investigations. Experimentally determined physicochemical parameters (pk(a)-value, partition coefficient) and the hydrogen-bonding ability of epinastine are indications that this compound will not easily cross the blood-brain barrier. This explains the absence of CNS side-effects of epinastine in pharmacological and clinical studies.