1278405-51-8 Usage
Description
(S)-2-(3-fluorophenyl)-4-(piperidin-3-ylamino)thieno[2,3-d]pyridazine-7-carboxamide hydrochloride is a compound with a thieno[2,3-d]pyridazine core structure and a piperidin-3-ylamino side chain. It is a hydrochloride salt form of a potential anticancer agent that is currently being studied for its potential in cancer therapy. (S)-2-(3-fluorophenyl)-4-(piperidin-3-ylamino)thieno[2,3-d]pyridazine-7-carboxamide hydrochloride has been shown to exhibit antitumor activity in in vitro and in vivo studies, and it is believed to work by inhibiting the growth of cancer cells. Preclinical studies have also suggested that the compound may have a favorable safety profile and low toxicity. Research is ongoing to further evaluate the potential of this compound as a therapeutic agent for cancer treatment.
Uses
Used in Pharmaceutical Industry:
(S)-2-(3-fluorophenyl)-4-(piperidin-3-ylamino)thieno[2,3-d]pyridazine-7-carboxamide hydrochloride is used as a potential anticancer agent for its demonstrated antitumor activity in both in vitro and in vivo studies. (S)-2-(3-fluorophenyl)-4-(piperidin-3-ylamino)thieno[2,3-d]pyridazine-7-carboxamide hydrochloride works by inhibiting the growth of cancer cells, making it a promising candidate for further research and development in cancer therapy.
Used in Oncology Research:
In the field of oncology, (S)-2-(3-fluorophenyl)-4-(piperidin-3-ylamino)thieno[2,3-d]pyridazine-7-carboxamide hydrochloride is used as a subject of preclinical studies to evaluate its safety profile, toxicity, and potential as a therapeutic agent for cancer treatment. (S)-2-(3-fluorophenyl)-4-(piperidin-3-ylamino)thieno[2,3-d]pyridazine-7-carboxamide hydrochloride's low toxicity and favorable safety profile make it an attractive option for further investigation and potential application in oncology.
Check Digit Verification of cas no
The CAS Registry Mumber 1278405-51-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,7,8,4,0 and 5 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1278405-51:
(9*1)+(8*2)+(7*7)+(6*8)+(5*4)+(4*0)+(3*5)+(2*5)+(1*1)=168
168 % 10 = 8
So 1278405-51-8 is a valid CAS Registry Number.
1278405-51-8Relevant articles and documents
Design, synthesis and evaluation of novel thienopyridazine derivatives as Chk1/2 inhibitors
Liu, Hanyu,Qian, Feng,Shen, Dadong,Wang, Pu
, (2022/03/07)
In order to search for novel checkpoint kinase 1/2 (Chk1) inhibitors, we have designed and synthesized a series of new compounds incorporating thienopyridazine core. Bioevaluation showed that compounds 10j, 10i, 13e and 10o exhibited relatively good inhibitory activity. Notably, compound 10o displayed high selectivity against a panel of kinases and inhibited Chk1/2 signaling pathway stimulated by DNA damage drugs in cellular level. Molecular docking of 10o to the ATP-binding site of Chk1 kinase domain indicated the existence of polar interactions between 10o and the ATP-ribose-binding residues of Chk1. In mouse HT-29 xenografts, a synergistic effect was observed. Co-treatment by CPT-11 and 10o significantly diminished the tumor volume, indicating the great potential of 10o as a candidate of Chk1/2 inhibitor.
