1279109-10-2Relevant articles and documents
Iodocyclization versus diiodination in the reaction of 3-alkynyl-4- methoxycoumarins with iodine: Synthesis of 3-iodofuro[2,3-b]chromones
Raffa, Guillaume,Belot, Sebastien,Balme, Genevieve,Monteiro, Nuno
experimental part, p. 1474 - 1478 (2011/04/15)
The reaction of 3-alkynyl-4-methoxycoumarins with molecular iodine in chlorinated solvents allows access to 3-iodofurochromones in good to excellent yields as the result of a iodocyclization-demethylation process. Competitive diiodination of the coumarin acetylene moiety could be eliminated by simply performing the reactions in refluxing 1,2-dichloroethane, owing to the thermal instability of the resulting (E)-1,2-diiodoethenylcoumarins. The Royal Society of Chemistry 2011.