127959-11-9

Basic information

• Product Name: (2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2 -amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxy-propanoyl]pyrroli dine-2-carbonyl]amino]-3-hydroxy-butanoyl]amino]-3-hydroxy-propanoyl]p yrrolidine-2-carbonyl]amino]-3-hydroxy-propanoyl]amino]-3-(4-hydroxyph enyl)propanoic acid
• Synonyms: (2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2 -amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxy-propanoyl]pyrroli dine-2-carbonyl]amino]-3-hydroxy-butanoyl]amino]-3-hydroxy-propanoyl]p yrrolidine-2-carbonyl]amino]-3-hydroxy-propanoyl]amino]-3-(4-hydroxyph enyl)propanoic acid;tyrosyl-seryl-prolyl-threonyl-seryl-prolyl-seryl-tyrosine
• CAS NO: 127959-11-9
• Molecular Formula: C₄₁H₅₆N₈O₁₅
• Molecular Weight: 900.9279
• Mol File: 127959-11-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 1439.2°Cat760mmHg
• Flash Point: 824.2°C
• Appearance: /
• Density: 1.464g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: (2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2 -amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxy-propanoyl]pyrroli dine-2-carbonyl]amino]-3-hydroxy-butanoyl]amino]-3-hydroxy-propanoyl]p yrrolidine-2-carbonyl]amino]-3-hydroxy-propanoyl]amino]-3-(4-hydroxyph enyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2 -amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxy-propanoyl]pyrroli dine-2-carbonyl]amino]-3-hydroxy-butanoyl]amino]-3-hydroxy-propanoyl]p yrrolidine-2-carbonyl]amino]-3-hydroxy-propanoyl]amino]-3-(4-hydroxyph enyl)propanoic acid(127959-11-9)
• EPA Substance Registry System: (2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2 -amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxy-propanoyl]pyrroli dine-2-carbonyl]amino]-3-hydroxy-butanoyl]amino]-3-hydroxy-propanoyl]p yrrolidine-2-carbonyl]amino]-3-hydroxy-propanoyl]amino]-3-(4-hydroxyph enyl)propanoic acid(127959-11-9)

Safety Data

• Hazardous Substances Data: 127959-11-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C41H56N8O15/c1-21(53)33(47-37(59)32-5-3-15-49(32)39(61)29(19-51)45-34(56)26(42)16-22-6-10-24(54)11-7-22)38(60)46-30(20-52)40(62)48-14-2-4-31(48)36(58)44-28(18-50)35(57)43-27(41(63)64)17-23-8-12-25(55)13-9-23/h6-13,21,26-33,50-55H,2-5,14-20,42H2,1H3,(H,43,57)(H,44,58)(H,45,56)(H,46,60)(H,47,59)(H,63,64)/t21-,26+,27+,28+,29+,30+,31+,32+,33+/m1/s1

Upstream product

• 4378-13-6 (O-tert-butyl)-L-threonine 
• 18822-58-7 (S)-O-tert-butylserine 
• 147-85-3 L-proline 

Relevant articles and documents

Linear heptapeptides containing DNA-intercalators. Synthesis and interaction with DNA

Five peptides of general structure X-Ser-Pro-Thr-Ser-Pro-Ser-Y (X = Tyr, quinoxaline2-carbonyl, acridine-9-carbonyl, Y = Tyr, (quinoxalin-2-yl)amino) were prepared using standard solid-phase peptide synthesis technique. Their interaction with DNA (calf thymus DNA and plasmids pUC9, pΔNS and pGEMEX) was studied using UV and CD spectroscopy, sedimentation analysis and agarose gel electrophoresis after treatment with topoisomerase 1. ln contrast to earlier findings (Suzuki M.: Nature 1990, 344, 562) intercalation into DNA structure has not been proved for any compound studied.