1280225-80-0

Basic information

• Product Name: C₂₉H₃₁N₃O₆
• Synonyms: C₂₉H₃₁N₃O₆
• CAS NO: 1280225-80-0
• Molecular Weight: 517.582
• Mol File: 1280225-80-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₉H₃₁N₃O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₃₁N₃O₆(1280225-80-0)
• EPA Substance Registry System: C₂₉H₃₁N₃O₆(1280225-80-0)

Safety Data

• Hazardous Substances Data: 1280225-80-0(Hazardous Substances Data)

Upstream product

• 64744-41-8 N-hydroxy-3-azaspiro[5,5]undecane-2,4-dione 
• 7432-21-5 N-carbobenzyloxy-L-tryptophane 

Downstream Products

• 17388-71-5 (2S)-2-{[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-(1H-indol-3-yl)propanoyl]amino}propanoic acid 

Relevant articles and documents

Synthesis of dipeptides from N-hydroxy-3-azaspiro[5,5]undecane-2,4-dione activated α-amino acids

A simple two step procedure for the synthesis of a dipeptide from N-hydroxy-3-azaspiro[5,5]undecane-2,4-dione (HO-ASUD) activated α-amino acids is described. In presence of DCC, N-hydroxy-3-azaspiro[5,5]undecane-2,4- dione readily esterifies the carboxylic acid group of all the N-protected amino acids to yield crystalline N-hydroxy-3-aza spiro[5,5]undecane-2,4-dione activated carboxy ester. The N-hydroxy-3-aza spiro[5,5]undecane-2,4-dione activated carboxy esters of N-protected amino acids readily condensed with other amino acids and gave a dipeptide. This new method is effective for the DCC coupling of a variety of chiral amino acids without loss of enantiomeric purity. Synthesis of fifteen dipeptides including the hitherto unreported Fmoc-l-Orn(Boc)-Val-OMe, Fmoc-l-Cys(trt)-Gly-OEt and Boc-l-Tyr-Gly-OEt is presented.