128252-98-2 Usage
Description
(6aS)-5-Chloro-9-[(2S,3R)-3-hydroxy-2-methyl-1-oxobutyl]-6aα-methyl-3-[(1E,3S)-3-methyl-1-pentenyl]-6H-furo[2,3-h]-2-benzopyran-6,8(6aH)-dione, also known as Chaetoviridin A, is an azaphilone antibiotic derived from the natural product of Chaetomium globosum. It is characterized by its unique structure, which includes a chloro group at position 5, a 3-hydroxy-2-methylbutanoyl group at position 9, a methyl group at position 6a, and a 3-methylpent-1-en-1yl group at position 3. (6aS)-5-Chloro-9-[(2S,3R)-3-hydroxy-2-methyl-1-oxobutyl]-6aα-methyl-3-[(1E,3S)-3-methyl-1-pentenyl]-6H-furo[2,3-h]-2-benzopyran-6,8(6aH)-dione exhibits potent antifungal activity against plant pathogenic fungi and has potential applications in various industries.
Uses
Used in Antifungal Applications:
Chaetoviridin A is used as an antifungal agent for the inhibition of plant pathogenic fungi. Its unique structure and potent activity make it a promising candidate for the development of new antifungal agents to combat fungal infections in agriculture and horticulture.
Used in Pharmaceutical Industry:
Chaetoviridin A is used as a lead compound in the development of new drugs targeting various diseases. Its ability to inhibit MAO and CETP makes it a potential candidate for the treatment of various conditions, including cancer and other diseases.
Used in Drug Delivery Systems:
To enhance the efficacy and bioavailability of Chaetoviridin A, novel drug delivery systems can be developed. These systems can improve the delivery of the compound to target cells and tissues, increasing its therapeutic potential and reducing side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 128252-98-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,2,5 and 2 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 128252-98:
(8*1)+(7*2)+(6*8)+(5*2)+(4*5)+(3*2)+(2*9)+(1*8)=132
132 % 10 = 2
So 128252-98-2 is a valid CAS Registry Number.
InChI:InChI=1/C23H25ClO6/c1-6-11(2)7-8-14-9-15-16(10-29-14)18-17(20(26)12(3)13(4)25)22(28)30-23(18,5)21(27)19(15)24/h7-13,25H,6H2,1-5H3/b8-7+/t11-,12-,13+,23-/m0/s1
128252-98-2Relevant articles and documents
Total Synthesis and Structural Revision of Chaetoviridins A
Makrerougras, Mehdi,Coffinier, Romain,Oger, Samuel,Chevalier, Arnaud,Sabot, Cyrille,Franck, Xavier
, p. 4146 - 4149 (2017/08/14)
The first synthesis of the proposed structures of chaetoviridins A 1-4 has been achieved in 10 steps by controlling the syn- or anti-aldol side chain. The angular lactone has been regioselectively introduced by condensation of a chiral dioxin-4-one to cazisochromene. Comparison of the NMR and circular dichroism data of the synthesized and reported natural products led to the complete reassignment and renaming of the chaetoviridins.
