1283129-18-9

Basic information

• Product Name: (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol 2,3,4,6-tetrakis(2,2-dimethylpropanoate)
• Synonyms: (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol 2,3,4,6-tetrakis(2,2-dimethylpropanoate);(2S,3S,4R,5R,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)Methyl)-4-Methylphenyl)-6-(pivaloyloxyMethyl) tetrahydro-2H-pyran-3,4,5-thiyl tris(2,2-diMethyl propanoate;Canagliflozin iMpurity E
• CAS NO: 1283129-18-9
• Molecular Formula: C₄₄H₅₇FO₉S
• Molecular Weight: 780.9813832
• Mol File: 1283129-18-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.19g/cm3 at 20℃
• Vapor Pressure: 0-0Pa at 20-25℃
• CAS DataBase Reference: (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol 2,3,4,6-tetrakis(2,2-dimethylpropanoate)(CAS DataBase Reference)
• NIST Chemistry Reference: (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol 2,3,4,6-tetrakis(2,2-dimethylpropanoate)(1283129-18-9)
• EPA Substance Registry System: (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol 2,3,4,6-tetrakis(2,2-dimethylpropanoate)(1283129-18-9)

Safety Data

• Hazardous Substances Data: 1283129-18-9(Hazardous Substances Data)

Upstream product

• 898566-17-1 (2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene) 
• 958300-05-5 2,3,4,6-tetra-O-pivaloyl-β-D-glucopyranosylbromide 
• 1283129-24-7 C₃₆H₂₈F₂S₂Zn 
• 3282-30-2 pivaloyl chloride 
• 492-62-6 alpha-D-glucopyranose 
• 81058-27-7 2,3,4,6-tetra-O-pivaloyl-α-D-glucopyranosyl bromide 

Downstream Products

• 842133-18-0 canagliflozin 

Relevant articles and documents

1 - (β - D - pyran glucosyl) - 4 - methyl - 3 - [5 - (4 - fluorophenyl) - 2 - thienyl methyl] benzene synthesis process

The invention discloses a preparation method of 1-(beta-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene. The method has the advantages of short route, no requirement on low temperature, solid starting raw materials and intermediate, convenience in purification, good stereoselectivity and the like.

PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT2

The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.