1283595-19-6

Basic information

• Product Name: (3R,4S)-1-((1S,2S,5S)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-2,2-difluoro-3-hydroxy-4-phenylpentan-1-one
• CAS NO: 1283595-19-6
• Molecular Weight: 336.422
• Mol File: 1283595-19-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,4S)-1-((1S,2S,5S)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-2,2-difluoro-3-hydroxy-4-phenylpentan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S)-1-((1S,2S,5S)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-2,2-difluoro-3-hydroxy-4-phenylpentan-1-one(1283595-19-6)
• EPA Substance Registry System: (3R,4S)-1-((1S,2S,5S)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-2,2-difluoro-3-hydroxy-4-phenylpentan-1-one(1283595-19-6)

Safety Data

• Hazardous Substances Data: 1283595-19-6(Hazardous Substances Data)

Upstream product

• 106927-67-7 (+)-1-<(1S,2S)-6,6-dimethylbicyclo<3.1.1>hept-2-yl>ethanone 
• 1283594-58-0 C₁₃H₁₇F₃O₂ 
• 1283594-70-6 1-((1S,2S,5S)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-2,2,4,4,4-pentafluoro-3,3-dihydroxybutan-1-one 
• 93-53-8 (R)-2-phenylpropanal 
• 93-53-8 (S)-2-phenyl-propionaldehyde 

Downstream Products

• 1283595-31-2 C₂₉H₃₄F₂O₄ 
• 1283595-32-3 C₂₉H₃₄F₂O₄ 

Relevant articles and documents

Cleavage of carbon-carbon bonds through the mild release of trifluoroacetate: Generation of α,α-difluoroenolates for aldol reactions

The selective cleavage of carbon-carbon bonds is a significant challenge in synthetic chemistry, yet this strategy can be a powerful way to generate reactive intermediates. We have discovered that, through the facile release of trifluoroacetate which occurs by C-C bond scission, difluoroenolates can be generated under very mild reaction conditions. Unlike existing reactions, this method is not limited to a small group of fluorinated building blocks. We have applied this process to the aldol reaction to install difluoromethylene groups.